Protein Info for ABID97_RS24870 in Variovorax sp. OAS795

Annotation: CDF family Co(II)/Ni(II) efflux transporter DmeF

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 319 transmembrane" amino acids 28 to 47 (20 residues), see Phobius details amino acids 59 to 76 (18 residues), see Phobius details amino acids 92 to 114 (23 residues), see Phobius details amino acids 128 to 148 (21 residues), see Phobius details amino acids 183 to 207 (25 residues), see Phobius details amino acids 213 to 231 (19 residues), see Phobius details TIGR01297: cation diffusion facilitator family transporter" amino acids 23 to 318 (296 residues), 216.5 bits, see alignment E=2.3e-68 PF01545: Cation_efflux" amino acids 28 to 239 (212 residues), 121.9 bits, see alignment E=1.5e-39

Best Hits

KEGG orthology group: None (inferred from 91% identity to vap:Vapar_4656)

Predicted SEED Role

"Cobalt-zinc-cadmium resistance protein CzcD" in subsystem Cobalt-zinc-cadmium resistance

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (319 amino acids)

>ABID97_RS24870 CDF family Co(II)/Ni(II) efflux transporter DmeF (Variovorax sp. OAS795)
MHTHDLRAWQHDHHFGAGNEKAERSTRLVMWITLAAMGIEIGAGWWFNSMALLADGWHMS
SHALAIGLSAFAYAAARRYARDPRFAFGTWKIEVLGGFASALMLLGVAALMVVGSIERLL
SPSAIHYREAVAVAVLGLVVNLVCARLLGSAHHHGHGHDHGHAHSAHDHGHSHGHDLNLR
SAYLHVVADAATSVLAIAALLGGWFFGWAWLDPAMGIVGAVLVAVWAKGLLKETGRVLLD
REMDHPVTAEIREGVETLLADSETRVADLHVWRVGREAYACALTVVTHSLTLSADEVRAC
FSMHEEIRHSTVEIQRCGH