Protein Info for ABID97_RS23530 in Variovorax sp. OAS795

Annotation: urease subunit alpha

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 590 PF00449: Urease_alpha" amino acids 3 to 132 (130 residues), 165.8 bits, see alignment E=7.3e-53 TIGR01792: urease, alpha subunit" amino acids 4 to 590 (587 residues), 924.9 bits, see alignment E=9.6e-283 PF01979: Amidohydro_1" amino acids 138 to 467 (330 residues), 262.2 bits, see alignment E=1.2e-81

Best Hits

Swiss-Prot: 94% identical to URE1_VARPS: Urease subunit alpha (ureC) from Variovorax paradoxus (strain S110)

KEGG orthology group: K01428, urease subunit alpha [EC: 3.5.1.5] (inferred from 94% identity to vap:Vapar_4243)

MetaCyc: 61% identical to urease subunit beta UreB (Helicobacter pylori 26695)

Predicted SEED Role

"Urease alpha subunit (EC 3.5.1.5)" in subsystem Urea decomposition (EC 3.5.1.5)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 3.5.1.5

Use Curated BLAST to search for 3.5.1.5

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (590 amino acids)

>ABID97_RS23530 urease subunit alpha (Variovorax sp. OAS795)
MATIGRRAYAEIFGPTVGDRVRLADTDLVIEVEADYTLRAGGYGEEVKFGGGKTIRDGMA
QSQRTRDGKASGPTAGGAVDTVLTNALILDHWGIVKADIGLKCGRIAAIGKAGNPDVQPG
VDIVIGPGTEIISCEGNIVTAGGIDSHIHFICPQQIEEALASGVTTMLGGGTGPATGTFA
TTATPGPWHIERMLQAADAFPMNLGFLGKGNASLPDALHEQIEAGVIGLKLHEDWGTTPS
AISNCLDVADATDTQVAIHSDTLNESGFVENTIAAVGGRSICAFHTEGAGGGHAPDILRV
VGEENFLPSSTNPTMPYTVNTLDEHVDMLMVCHHLDAGIAEDLAFAESRIRKETIAAEDV
LHDLGAISMFSSDSQAMGRVGEVVLRCWQTAHKMKLQRGWLPPAPGAGAGSVDSNERNDN
FRARRYVAKYTINPAIAHGIAHEVGSLEVGKWADIVIWKPAFFGVKPFTLIKGGTIAMAA
MGDPNASIPTPQPVHYRPMFGSYGGSLAKSSLTFVSQAGLAAGIKERYGLAKHLSAVKNI
RNVRKKDLIHNSYTPKMEIDAQTYAVRADGHLLTCDPAVQLPLTQRYFLF