Protein Info for ABID97_RS20690 in Variovorax sp. OAS795

Annotation: fumarylacetoacetate hydrolase family protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF01557: FAA_hydrolase
  • amino acids 58 to 263 (206 residues), 184.9 bits, E=8.1e-59

Best Hits

KEGG orthology group: None (inferred from 93% identity to vap:Vapar_3551)

MetaCyc: 51% identical to 3-fumarylpyruvate hydrolase (Bradyrhizobium sp. JS329)
RXN-10445 [EC: 3.7.1.20]

Predicted SEED Role

"Fumarylacetoacetase (EC 3.7.1.2)" in subsystem Homogentisate pathway of aromatic compound degradation or Salicylate and gentisate catabolism (EC 3.7.1.2)

MetaCyc Pathways

• L-tyrosine degradation I (5/5 steps found)
• gentisate degradation I (2/3 steps found)
• 3-phenylpropanoate degradation (5/10 steps found)
• 5-nitroanthranilate degradation (2/6 steps found)

KEGG Metabolic Maps

• Styrene degradation
• Tyrosine metabolism

Isozymes

Compare fitness of predicted isozymes for: 3.7.1.2

Use Curated BLAST to search for 3.7.1.2 or 3.7.1.20

Protein Sequence (263 amino acids)

>ABID97_RS20690 fumarylacetoacetate hydrolase family protein (Variovorax sp. OAS795)
MSSSRRGLLAGSAAMAAGAMTGCALPAGASRAAPTPFTVAQATVPIVGSEQAFPVRRIYC
IGRNYAAHAREMGSDPTREPPFFFQKPTDAIQVVTPGTVADHPYPPLTKNYHYEVELVVA
LGKGGRDVAQADALGLVYGYSLGLDMTRRDLQREMGDQKKPWEIGKSFDKSAPIGPIHPV
ARVGHYTDGAIWLKVNGQTKQNATLKHMIWSVAEQISRLSQAFELMPGDIIYSGTPENVG
PVVRGDLIEIHIDGLPNLSVRVV