Protein Info for ABID97_RS19740 in Variovorax sp. OAS795

Annotation: sensor histidine kinase N-terminal domain-containing protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 472 signal peptide" amino acids 1 to 46 (46 residues), see Phobius details transmembrane" amino acids 183 to 204 (22 residues), see Phobius details PF08521: 2CSK_N" amino acids 28 to 172 (145 residues), 118.9 bits, see alignment E=2.8e-38 PF00512: HisKA" amino acids 251 to 314 (64 residues), 30.3 bits, see alignment E=5.3e-11 PF02518: HATPase_c" amino acids 361 to 467 (107 residues), 66.8 bits, see alignment E=3.4e-22

Best Hits

KEGG orthology group: K07649, two-component system, OmpR family, sensor histidine kinase TctE [EC: 2.7.13.3] (inferred from 93% identity to vpe:Varpa_2286)

Predicted SEED Role

"Tricarboxylate transport sensor protein TctE"

Isozymes

Compare fitness of predicted isozymes for: 2.7.13.3

Use Curated BLAST to search for 2.7.13.3

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (472 amino acids)

>ABID97_RS19740 sensor histidine kinase N-terminal domain-containing protein (Variovorax sp. OAS795)
MRAARVVANRLRRASLWQRLALLLFPALLVVTGLELWMTRHDALAAANAAYDRSLLGALK
SIDANISTAAGGLSVELPYTMFEFFELTASGQVFFRVATSDGLVELGSADLPAPPTQLAM
GVPAFYDAAYFGEAVRLAAYRRDLDRAPAGSSGRSVLIQVGESTRSREEFSTRFVRSAAL
RDGLVLAMLFCGTALALAAALRPLSRLAREVQARRPDDLTRIAATDLPAEVRPLVDAVNQ
QMSRTQDLVTQQRQFLDDASHQLRTHLTTLQMQADYARREEDPAQVRAALDALGTEIGRA
TRSAQQLLALGRSDTVAVEPAEFDLAALLREVAVDLLPLARAKRIDLGIHSPSPEFLAVA
DRGLLREALVNLVANAIAYTPAEGTITLFAAGDAAGWSLNVEDDGPGLGDEERGTLGQRF
SRGARAGKGGFGLGLAIARSIAHRHRGELRLEARPGTTGLHAIIWWPRPAAS