Protein Info for ABID97_RS19655 in Variovorax sp. OAS795

Annotation: aminomethyl-transferring glycine dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 850 900 968 PF02347: GDC-P" amino acids 21 to 448 (428 residues), 591.7 bits, see alignment E=8.8e-182 amino acids 467 to 745 (279 residues), 40.5 bits, see alignment E=1.7e-14 TIGR00461: glycine dehydrogenase" amino acids 21 to 956 (936 residues), 1431.6 bits, see alignment E=0 PF21478: GcvP2_C" amino acids 784 to 905 (122 residues), 195 bits, see alignment E=3.3e-62

Best Hits

KEGG orthology group: K00281, glycine dehydrogenase [EC: 1.4.4.2] (inferred from 77% identity to ajs:Ajs_1936)

Predicted SEED Role

"Glycine dehydrogenase [decarboxylating] (glycine cleavage system P protein) (EC 1.4.4.2)" in subsystem Glycine and Serine Utilization or Glycine cleavage system or Photorespiration (oxidative C2 cycle) (EC 1.4.4.2)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.4.4.2

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (968 amino acids)

>ABID97_RS19655 aminomethyl-transferring glycine dehydrogenase (Variovorax sp. OAS795)
MSSHALPSLQELENAEEFLARHIGIDAADEARMLPVIGSETRAELIDGIVPAAIRRARRM
RLPAPVSEADALAELKAIAAKNKVFKSFIGQGYYGTHTPGVILRNVLENPAWYTAYTPYQ
AEISQGRMEALLNFQTMVCDLTGMAIANASMLDEATAAAEAMTLAKRSVKSKSNVFLVSG
DCHPQTIEVIRTRAAPLGIEVRVSTVSETLPHLMASCEFFGVLAQYPATTGHVHDLRPLA
GHAHQCDAAFCVAADLLALTLLAPPGEWDADIVCGTTQRFGMPLCNGGPHAAYLACRDEF
KRSLPGRLVGVSVDTHGQPAYRLALQTREQHIRREKATSNICTAQVLPAVVASMYAVYHG
PDGLTRIAQRVAALTAILAQGLAQMGREPVNATAFDSLTIRTGEDTQKIIERAQAAGVNL
RQRLQQHLGISLDETTTRADIETLWALFVPAGTPMPRFDDLANTAPRLPEDLRRTSAFLT
HPVFNTHKSETAMLRYIRSLSDKDLALDRSMIPLGSCTMKLNATSEMIPITWPEFANIHP
FAPAEQLVGYAQLDAQLRAWLCEATGYAGISLQPNAGSQGEYAGLLAIRSFHEANGQGHR
NICLIPSSAHGTNPASAQMVGLQVVVTACDAQGNVDMDDLKRACERHSDKLAAVMITYPS
THGVFETRVKELCELVHEHGGRVYVDGANMNALVGVAAPGEFGGDVSHLNLHKTFCIPHG
GGGPGVGPVCVVEDLVPYLPGHATGGIASNGVGAVSAAPLGNAAVLPISWMYCRMMGAKG
LQAATEIAILSANYISARLKDHYPTLYASPNGHVAHECILDLRPLKDTSGVTAEDVAKRL
IDYGFHAPTLSFPVPGTLMVEPTESEPLAELDRFIDAMIAIRGEIRRVEEGVWPKDDNPL
KHAPHTAASLLGTEWPHPYSRELGAFPLAELKQAKYWPPIGRVDNVYGDRNLFCSCVPVG
DYQEAEAA