Protein Info for ABID97_RS19050 in Variovorax sp. OAS795

Annotation: NAD-dependent succinate-semialdehyde dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00171: Aldedh
  • amino acids 2 to 450 (449 residues), 480 bits, E=3.3e-148

Best Hits

Swiss-Prot: 49% identical to GABD_SYNY3: Probable succinate-semialdehyde dehydrogenase [NADP(+)] (gabD) from Synechocystis sp. (strain PCC 6803 / Kazusa)

KEGG orthology group: K00135, succinate-semialdehyde dehydrogenase (NADP+) [EC: 1.2.1.16] (inferred from 68% identity to rhi:NGR_c25860)

MetaCyc: 50% identical to succinate-semialdehyde dehydrogenase monomer (Synechococcus sp. PCC 7002)
SUCCSEMIALDDEHYDROG-RXN [EC: 1.2.1.79]

Predicted SEED Role

"Succinate-semialdehyde dehydrogenase [NAD] (EC 1.2.1.24); Succinate-semialdehyde dehydrogenase [NAD(P)+] (EC 1.2.1.16)" (EC 1.2.1.16, EC 1.2.1.24)

MetaCyc Pathways

• TCA cycle IV (2-oxoglutarate decarboxylase) (8/9 steps found)
• superpathway of 4-aminobutanoate degradation (3/3 steps found)
• 4-aminobutanoate degradation I (2/2 steps found)
• 4-aminobutanoate degradation II (2/2 steps found)
• 4-aminobutanoate degradation III (2/2 steps found)
• GABA shunt I (3/4 steps found)
• GABA shunt II (3/4 steps found)
• superpathway of L-arginine and L-ornithine degradation (9/13 steps found)
• 4-hydroxyphenylacetate degradation (5/8 steps found)
• superpathway of L-arginine, putrescine, and 4-aminobutanoate degradation (7/11 steps found)
• 4-aminobutanoate degradation IV (1/3 steps found)
• N-methylpyrrolidone degradation (1/3 steps found)
• nicotine degradation II (pyrrolidine pathway) (5/11 steps found)
• nicotine degradation I (pyridine pathway) (5/17 steps found)

KEGG Metabolic Maps

• Butanoate metabolism
• Glutamate metabolism
• Tyrosine metabolism

Isozymes

Compare fitness of predicted isozymes for: 1.2.1.16

Use Curated BLAST to search for 1.2.1.16 or 1.2.1.24 or 1.2.1.79

Protein Sequence (456 amino acids)

>ABID97_RS19050 NAD-dependent succinate-semialdehyde dehydrogenase (Variovorax sp. OAS795)
MINTTNPVTEVIEARFDAHTAEQVEQLLEGAANAQRQWAQTPLSARLPLLHRVAGVLREN
KAAYARLITMEMGKPIVEAEGEIEKCAVTCEFYAENAPRFLSDMTVESNATESSVVFDPL
GIVLAVMPWNYPFWQFVRFAAPALAAGNGALLKHANNVPQCALALQDAFVKAGAPEGLVT
TLLVEASEVAGLIADRRVAAVTLTGSTAVGKIVAAQAGAVMKKQVLELGGSDPFIVLADA
DIEEAAKVATKARFTNTGQSCICAKRFLVEESVADRFVEALCAHASELKIGDPMQRDTSV
GPMARGNLRDELHSQVQRTIAAGAKLLLGGAPVEGPGYFYPPTVMDHVTPDMAAAKEETF
GPAAAVIRVKDADEAVRLANATEFGLGAALWTRDLERAKSLARRIEAGAVFINGLVASDA
RLPFGGIKQSGYGRELGEFGIREFTNIKTVWIGPTR