Protein Info for ABID97_RS17340 in Variovorax sp. OAS795

Annotation: cobyric acid synthase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 479 TIGR00313: cobyric acid synthase CobQ" amino acids 6 to 440 (435 residues), 402.4 bits, see alignment E=1.5e-124 PF13500: AAA_26" amino acids 6 to 226 (221 residues), 44.2 bits, see alignment E=3.1e-15 PF01656: CbiA" amino acids 6 to 214 (209 residues), 62.3 bits, see alignment E=6.6e-21 PF07685: GATase_3" amino acids 252 to 440 (189 residues), 149.6 bits, see alignment E=1.3e-47

Best Hits

Swiss-Prot: 95% identical to COBQ_VARPS: Cobyric acid synthase (cobQ) from Variovorax paradoxus (strain S110)

KEGG orthology group: K02232, adenosylcobyric acid synthase [EC: 6.3.5.10] (inferred from 95% identity to vap:Vapar_2565)

MetaCyc: 45% identical to adenosyl-cobyrate synthase subunit (Salmonella enterica enterica serovar Typhimurium)
Adenosylcobyric acid synthase (glutamine-hydrolyzing). [EC: 6.3.5.10]

Predicted SEED Role

"Cobyric acid synthase (EC 6.3.5.10)" (EC 6.3.5.10)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 6.3.5.10

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (479 amino acids)

>ABID97_RS17340 cobyric acid synthase (Variovorax sp. OAS795)
MTTRCVMVLGTTSGAGKSWLVTALCRWYARQGLKVAPFKAQNMSNNARVVDGGEIGSAQY
FQALAARAVPDVRMNPLLLKPERDTHSQVVLMGQVSEELTAMPWRGRSERVWPQIAEAFD
ALRAENDVVVIEGAGSPAEINLMASDIVNLRVARHADARCLLVTDIDRGGAFAHLYGTWA
LMPESDRALLRGFVLNKFRGDASLLAPAPQQLQALTGIATVATLPMWWQHGLPEEDGVFD
DRSHASGPVTRTVAVVVYPRISNLDEFQPLKNVPGVRLVWARSPADVAGAGWIVLPGSKH
TSGDLAWLRAQGLDRAIAAHAAGGGAVLGVCGGLQMLGEALVDPHGIDGNAPGLGLLPLV
TVFEREKTVRHRSAVFGALNGPWAALSNVPVAGYEIHHGQTAVHPQMAQDGQAVMPEGLA
WQNARGNVLGLYLHGLFEDEAALHALFGAAAPTLDATFDGLADFIDTHFEPGVLQGLIA