Protein Info for ABID97_RS17290 in Variovorax sp. OAS795

Annotation: phosphoserine phosphatase SerB

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 236 TIGR00338: phosphoserine phosphatase SerB" amino acids 23 to 235 (213 residues), 236.2 bits, see alignment E=3.2e-74 PF00702: Hydrolase" amino acids 25 to 204 (180 residues), 83 bits, see alignment E=9.3e-27 PF06888: Put_Phosphatase" amino acids 26 to 197 (172 residues), 27.1 bits, see alignment E=6.8e-10 TIGR01488: HAD phosphoserine phosphatase-like hydrolase, family IB" amino acids 26 to 201 (176 residues), 111.3 bits, see alignment E=5.1e-36 PF12710: HAD" amino acids 27 to 200 (174 residues), 84.7 bits, see alignment E=2.9e-27 PF08282: Hydrolase_3" amino acids 165 to 219 (55 residues), 40.3 bits, see alignment E=8.3e-14

Best Hits

Swiss-Prot: 75% identical to SERB_POLSJ: Phosphoserine phosphatase (serB) from Polaromonas sp. (strain JS666 / ATCC BAA-500)

KEGG orthology group: K01079, phosphoserine phosphatase [EC: 3.1.3.3] (inferred from 95% identity to vpe:Varpa_3345)

Predicted SEED Role

"Phosphoserine phosphatase (EC 3.1.3.3)" in subsystem Glycine and Serine Utilization or Serine Biosynthesis (EC 3.1.3.3)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 3.1.3.3

Use Curated BLAST to search for 3.1.3.3

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (236 amino acids)

>ABID97_RS17290 phosphoserine phosphatase SerB (Variovorax sp. OAS795)
MSATEISPGLVIQRVKPPLKLADFQLIAFDMDSTLINIECIDEIADAVGKKAEVAAITEA
TMRGEIKDFKESLRRRVALLKGVPVEALQQVYDQRLELNPGAAELVAACKAAGLKVLLVS
GGFTFFANRVKDRLGIDFARSNLLDEADGRLTGQVVQQSWGDICDGAEKRRTLLEVASLM
GISPQETIAVGDGANDLPMMGEAGLSVAYHAKPKVREQAMVAINEGGLDRLLEILK