Protein Info for ABID97_RS17135 in Variovorax sp. OAS795

Annotation: RIP metalloprotease RseP

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 456 signal peptide" amino acids 1 to 22 (22 residues), see Phobius details amino acids 25 to 27 (3 residues), see Phobius details transmembrane" amino acids 100 to 124 (25 residues), see Phobius details amino acids 383 to 404 (22 residues), see Phobius details amino acids 433 to 452 (20 residues), see Phobius details TIGR00054: RIP metalloprotease RseP" amino acids 1 to 455 (455 residues), 308.3 bits, see alignment E=4.2e-96 PF02163: Peptidase_M50" amino acids 6 to 441 (436 residues), 205.9 bits, see alignment E=5.4e-65 PF17820: PDZ_6" amino acids 230 to 271 (42 residues), 34.5 bits, see alignment 1.5e-12

Best Hits

KEGG orthology group: K11749, regulator of sigma E protease [EC: 3.4.24.-] (inferred from 92% identity to vap:Vapar_2606)

Predicted SEED Role

"Membrane-associated zinc metalloprotease" in subsystem Sex pheromones in Enterococcus faecalis and other Firmicutes

Isozymes

Compare fitness of predicted isozymes for: 3.4.24.-

Use Curated BLAST to search for 3.4.24.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (456 amino acids)

>ABID97_RS17135 RIP metalloprotease RseP (Variovorax sp. OAS795)
MLTVIAFVVALGVLIAVHEYGHYRVAVACGVKVLRFSVGFGKTLYRWQPKRQHPGQQTEF
VIGAFPLGGYVKMLDEREGPVAPEELHRAFNRQPLRSRAAIVAAGPIANLLLAVVLYTAV
NWIGVDEPVARLGRPVAASLAEAAGLRGGEHVTRAGFEGDLEPVQSFEDLRWRMTRGALD
ARDLTLEIAGEGGQPARQVVLPLSRIAAKDADPQMFRKIGVIAPLTQPEIGQVMAGSAAE
RAGLRSGDLVRAVGNTAIVDGQQLREVIRTSIDGDQPRAQTWQVRRGGQPVALEVKPELR
EEAGVKVGRIGAYVGAPPEMVTVRQGPVDGVWRGIVRTWEVSALTVRMMGKMVIGEASLK
NLSGPLTIADYAGKSASLGLTQYLVFLALISVSLGVLNLMPLPVLDGGHLMYYLWEGLTG
KSVSDAWMERLQRGGVALLLVMMSVALFNDVTRLFG