Protein Info for ABID97_RS16580 in Variovorax sp. OAS795

Annotation: leucyl aminopeptidase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF02789: Peptidase_M17_N
  • amino acids 35 to 133 (99 residues), 29.1 bits, E=8.2e-11
• PF00883: Peptidase_M17
  • amino acids 172 to 473 (302 residues), 410 bits, E=6.7e-127

Best Hits

Swiss-Prot: 92% identical to AMPA_VARPS: Probable cytosol aminopeptidase (pepA) from Variovorax paradoxus (strain S110)

KEGG orthology group: K01255, leucyl aminopeptidase [EC: 3.4.11.1] (inferred from 92% identity to vap:Vapar_2730)

Predicted SEED Role

"Cytosol aminopeptidase PepA (EC 3.4.11.1)" (EC 3.4.11.1)

KEGG Metabolic Maps

• Glutathione metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.4.11.1

Protein Sequence (509 amino acids)

>ABID97_RS16580 leucyl aminopeptidase (Variovorax sp. OAS795)
MDFQLKTLTVARAAAEKSDLLIVLVGSAPLTAKDPLSALIASARKAGDLPDKAGKLLSLY
QPDEVVAPRVVLAAIGDGKPASVRSGVIAAVNAAKANGPKRVTMVFAQDADGAAVAGAVA
AAADASYVYTTTKPSNGENGRTIRNLTLGLPNAAALGKAFDEARATVAGIEFAKEWGNRP
GNYCTPTLLADAAKGLGKLPRIKCEVLGPKEVQKLGMGSFAAVAQGSAEPLRFIVLRYQG
GPRDQAPVVLVGKGITFDTGGVSLKPAAEMDEMKFDMCGAASVLGTFRALGEIQPAINVV
GLVPTCENMNDGRAIKPGDVVTSMSGQTIEVLNTDAEGRLILCDALTYAKRFEPAAVIDI
ATLTGACVVALGGVRSGLFTADETLAAALQAAGEESQDRCWRLPLDDEYAEGLKSNFADV
ANVAGRAGGAITAAKFLQRFAGDFAWAHLDIAGTAWKSGAAKGSTGRPVGLLVSYLMARA
RGDAAAAAAAPKAARKSTGSASRKARSAQ