Protein Info for ABID97_RS14070 in Variovorax sp. OAS795

Annotation: ribose-5-phosphate isomerase RpiA

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR00021: ribose 5-phosphate isomerase A
  • amino acids 25 to 236 (212 residues), 217.8 bits, E=6e-69
• PF06026: Rib_5-P_isom_A
  • amino acids 67 to 235 (169 residues), 193.4 bits, E=1.2e-61

Best Hits

Swiss-Prot: 77% identical to RPIA_POLSJ: Ribose-5-phosphate isomerase A (rpiA) from Polaromonas sp. (strain JS666 / ATCC BAA-500)

KEGG orthology group: K01807, ribose 5-phosphate isomerase A [EC: 5.3.1.6] (inferred from 92% identity to vap:Vapar_2156)

MetaCyc: 61% identical to ribose-5-phosphate isomerase A (Escherichia coli K-12 substr. MG1655)
Ribose-5-phosphate isomerase. [EC: 5.3.1.6]

Predicted SEED Role

"Ribose 5-phosphate isomerase A (EC 5.3.1.6)" in subsystem Calvin-Benson cycle or D-ribose utilization or Pentose phosphate pathway (EC 5.3.1.6)

MetaCyc Pathways

• Bifidobacterium shunt (14/15 steps found)
• Rubisco shunt (10/10 steps found)
• photosynthetic 3-hydroxybutanoate biosynthesis (engineered) (21/26 steps found)
• pentose phosphate pathway (8/8 steps found)
• superpathway of glucose and xylose degradation (14/17 steps found)
• Calvin-Benson-Bassham cycle (11/13 steps found)
• pentose phosphate pathway (non-oxidative branch) I (5/5 steps found)
• formaldehyde assimilation III (dihydroxyacetone cycle) (10/12 steps found)
• ethene biosynthesis V (engineered) (19/25 steps found)
• pentose phosphate pathway (non-oxidative branch) II (5/6 steps found)
• 1-butanol autotrophic biosynthesis (engineered) (20/27 steps found)
• formaldehyde assimilation II (assimilatory RuMP Cycle) (7/9 steps found)
• oxygenic photosynthesis (12/17 steps found)

KEGG Metabolic Maps

• Biosynthesis of alkaloids derived from histidine and purine
• Biosynthesis of plant hormones
• Carbon fixation in photosynthetic organisms
• Pentose phosphate pathway

Isozymes

No predicted isozymes

Use Curated BLAST to search for 5.3.1.6

Protein Sequence (242 amino acids)

>ABID97_RS14070 ribose-5-phosphate isomerase RpiA (Variovorax sp. OAS795)
MTAPVSPSSVPGDGATGAISKDELKAQVGRAALAYVAKGEIVGVGTGSTVNKFIDALATI
KDQIKGAVSSSVASTERLRALGIPVFDSNEVEELGVYIDGADEIDHHGFMVKGGGAALTR
EKIVAAQSRRFVCIADASKLVDVLGAFPLPVEVIPMAARRVMRQFEAMGGIAQVREKDGL
PLVTDNGQHIVDVTGLRISDPLAFESEVSQWPGVVTVGVFAHQKAHVCLLGTASGVQTLR
FD