Protein Info for ABID97_RS14065 in Variovorax sp. OAS795

Annotation: quinone-dependent dihydroorotate dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR01036: dihydroorotate dehydrogenase (fumarate)
  • amino acids 9 to 352 (344 residues), 386.1 bits, E=6.4e-120
• PF01180: DHO_dh
  • amino acids 53 to 352 (300 residues), 263.7 bits, E=1e-82

Best Hits

Swiss-Prot: 77% identical to PYRD_POLSJ: Dihydroorotate dehydrogenase (quinone) (pyrD) from Polaromonas sp. (strain JS666 / ATCC BAA-500)

KEGG orthology group: K00226, dihydroorotate dehydrogenase (fumarate) [EC: 1.3.98.1] (inferred from 94% identity to vap:Vapar_2155)

Predicted SEED Role

"Dihydroorotate dehydrogenase (EC 1.3.3.1)" in subsystem De Novo Pyrimidine Synthesis (EC 1.3.3.1)

MetaCyc Pathways

• UMP biosynthesis II (6/6 steps found)

KEGG Metabolic Maps

• Pyrimidine metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.3.3.1 or 1.3.98.1

Protein Sequence (360 amino acids)

>ABID97_RS14065 quinone-dependent dihydroorotate dehydrogenase (Variovorax sp. OAS795)
MPLLPSSLYGLARPFLFGFDPEHAHELTLDGLARTQNTPLACAYAAPRVDDPVTLAGLQF
PNRVGLAAGLDKNARCIDAFAAMGFGFVEVGTVTPKAQPGNPKPRMFRLPQRDALINRLG
FNNEGLDAFLANVQKARFRKNAGGTGRKPMLLGLNIGKNATTPIERAVDDYLACLDGVYA
HADYVTINISSPNTANLRTLQSDEALDALLGAMAERRQALAERGGRRVPLFVKIAPDLDE
GQVAVIAATLQRHGMDGVIATNTTLARDAVAGLPHAGEAGGLSGAPVREASNRVIAQLRA
ALGAAFPIIGVGGVLSAADAKAKIEAGADVVQIYTGLIYRGPALVREAAQALLQQGRSAA