Protein Info for ABID97_RS13905 in Variovorax sp. OAS795

Annotation: DNA cytosine methyltransferase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 733 signal peptide" amino acids 1 to 25 (25 residues), see Phobius details transmembrane" amino acids 370 to 391 (22 residues), see Phobius details PF00145: DNA_methylase" amino acids 5 to 326 (322 residues), 224.2 bits, see alignment E=1.5e-70 amino acids 369 to 710 (342 residues), 192.5 bits, see alignment E=6.7e-61 TIGR00675: DNA (cytosine-5-)-methyltransferase" amino acids 7 to 324 (318 residues), 182.3 bits, see alignment E=9.4e-58 amino acids 369 to 704 (336 residues), 153.2 bits, see alignment E=6.7e-49

Best Hits

Predicted SEED Role

"DNA-cytosine methyltransferase (EC 2.1.1.37)" (EC 2.1.1.37)

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 2.1.1.37

Use Curated BLAST to search for 2.1.1.37

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (733 amino acids)

>ABID97_RS13905 DNA cytosine methyltransferase (Variovorax sp. OAS795)
MKKLTSISLFAGGGGMTLGTTAAGFETLFATDVKPSAEETFRHNFPDVPFFAGDVRRLTR
DYLEKIIDGRKVDLIVGGPPCQGFSTIGDQNPADPRNGLFWCFARIVEWIKPSCVLMENV
NYLRTQYGGRFEREIIAAFERLGYRMWVTTLNSADFGVPQIRKRVFFFGTRLKTGFAWPK
VTHGTETNPHVPVWSVLSDLSGPRDDIANHSFLRHGEIVVSRYQLIPEGGRMPPPSELPE
AIRRKNFGNTYKRLHRERPALTMVPGNNAFPIHPVENRSLSPREAARIQTFPDSYVFSGS
RAEQCQLVGNAVPVLLAKQLGEQIKRHIQGKITVSEQKPTTKLSGEEIALAAFKEAEAKP
ARRTGPTAVSFFSGVGGLMLGFLNAGCNVLASYDKKNSVDRNQKLNFPDVPHFVSDAALL
TVEEIRKNTKNKQIDIVFGGPPCQGFSIFGRRRFINTQDHKPEDDERNDLSIKYIELAIG
LSPKAIFLENVKGFVSTQRGNSTYLAEVEKKLKRAGYEVAHKVVNCADYGVPQQRERFIL
VAWKKGLMFQWPEPKYFSDPKSWQRPYVTVGDVISDLMDPATCGDEFSHAPMAHKELVVA
RYKLIPEGGRLPENGLPEHLRKGYRSDNVKNYSHVYKRLSMGSPATTMVPGHNAFPVHPV
LHRTLTVREAARIQTFPDWMRFIGTRQQQCTLVGNAVPPVLAEIFACNIVKTIKGNYSSR
GYKRDVYDLAASP