Protein Info for ABID97_RS13665 in Variovorax sp. OAS795

Annotation: HyaD/HybD family hydrogenase maturation endopeptidase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 211 TIGR00140: hydrogenase expression/formation protein" amino acids 7 to 158 (152 residues), 211.2 bits, see alignment E=6.9e-67 TIGR00072: hydrogenase maturation protease" amino acids 9 to 151 (143 residues), 148 bits, see alignment E=1.9e-47 PF01750: HycI" amino acids 24 to 150 (127 residues), 141.9 bits, see alignment E=5.5e-46

Best Hits

Swiss-Prot: 72% identical to HOXM_CUPNH: Hydrogenase expression/formation protein HoxM (hoxM) from Cupriavidus necator (strain ATCC 17699 / H16 / DSM 428 / Stanier 337)

KEGG orthology group: K03605, hydrogenase 1 maturation protease [EC: 3.4.24.-] (inferred from 79% identity to mpt:Mpe_A2822)

Predicted SEED Role

"Hydrogenase maturation protease (EC 3.4.24.-)" in subsystem Membrane-bound Ni, Fe-hydrogenase (EC 3.4.24.-)

Isozymes

Compare fitness of predicted isozymes for: 3.4.24.-

Use Curated BLAST to search for 3.4.24.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (211 amino acids)

>ABID97_RS13665 HyaD/HybD family hydrogenase maturation endopeptidase (Variovorax sp. OAS795)
MAPDETICVLGIGNVLWADEGFGVRCVEALQRRYEFAPHVALIDGGTQGLYLIQHVQQAT
RLLIFDAIDYGLPAGTLKLIEDDEVPRFMGAKKMSLHQTGFQEVLMLAQLTERYPQRVLL
VGCQPEELDDYGGSLRPCVKLAMEDALALGVDELRRWGAVPRPRRHPLASPEAVTFRQLD
LDRYEAERPDEDAACRLGDERFLPALAGQPA