Protein Info for ABID97_RS13615 in Variovorax sp. OAS795

Annotation: HypC/HybG/HupF family hydrogenase formation chaperone

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 25 50 81 TIGR00074: hydrogenase assembly chaperone HypC/HupF" amino acids 1 to 76 (76 residues), 73.2 bits, see alignment E=5.9e-25 PF01455: HupF_HypC" amino acids 1 to 66 (66 residues), 88.5 bits, see alignment E=1.3e-29

Best Hits

Swiss-Prot: 64% identical to HYPC_CUPNH: Hydrogenase maturation factor HypC (hypC) from Cupriavidus necator (strain ATCC 17699 / H16 / DSM 428 / Stanier 337)

KEGG orthology group: K04653, hydrogenase expression/formation protein HypC (inferred from 72% identity to mpt:Mpe_A2813)

Predicted SEED Role

"[NiFe] hydrogenase metallocenter assembly protein HypC" in subsystem NiFe hydrogenase maturation

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (81 amino acids)

>ABID97_RS13615 HypC/HybG/HupF family hydrogenase formation chaperone (Variovorax sp. OAS795)
MCLAIPTQLIELRPGALGLVELGGIRKEISVALVPDAVVGDYVIVHVGHAIGRIDPEEAR
RTLAMFGTLSELAAANEAALP