Protein Info for ABID97_RS11855 in Variovorax sp. OAS795

Annotation: UDP-glucose/GDP-mannose dehydrogenase family protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 461 signal peptide" amino acids 1 to 21 (21 residues), see Phobius details PF03721: UDPG_MGDP_dh_N" amino acids 1 to 197 (197 residues), 198.3 bits, see alignment E=1.4e-62 TIGR03026: nucleotide sugar dehydrogenase" amino acids 1 to 443 (443 residues), 422 bits, see alignment E=1.2e-130 PF00984: UDPG_MGDP_dh" amino acids 220 to 311 (92 residues), 129.1 bits, see alignment E=8.6e-42 PF03720: UDPG_MGDP_dh_C" amino acids 335 to 447 (113 residues), 103.8 bits, see alignment E=8.8e-34

Best Hits

KEGG orthology group: K00012, UDPglucose 6-dehydrogenase [EC: 1.1.1.22] (inferred from 90% identity to vpe:Varpa_3050)

Predicted SEED Role

"UDP-glucose dehydrogenase (EC 1.1.1.22)" in subsystem Lipid A-Ara4N pathway ( Polymyxin resistance ) or Teichuronic acid biosynthesis (EC 1.1.1.22)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 1.1.1.22

Use Curated BLAST to search for 1.1.1.22

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (461 amino acids)

>ABID97_RS11855 UDP-glucose/GDP-mannose dehydrogenase family protein (Variovorax sp. OAS795)
MKISVLGTGYVGLVTGSCLAELGNEVFCFDVDQRKVEILQSGGVPIHEEGLPQLIERNVR
TGRLHFTTDVARAVHHGDLIFIAAGTPPGQDGSADLQYVIAAGRSIGRHMQGFKVVVEKS
TVPVGTAGKLRAAIEEELSQRRSNGDHAAGSGLHGVPVAIVSNPEFLKEGAAVDDFMRPD
RIVVGTEPGEEGRQAREVMTRLYAPFNRQRDRMIHMDVKAAEFTKYAANAMLATRISFMN
ELANLAEKVGVDIEQVRRGVGSDPRIGYSFLYAGLGYGGSCFPKDVQALVHTAATHGQRL
HVLEAVRAVNDAQKLVLIEKIVRRFGEDLRGRRFGIWGLAFKPDTDDMREAPSRIVIKAL
LVRGAEVVAHDPVAIPEARRVLASDLDGMPELLARLSYVDNPMQAAEDADALVVLTDWKA
FKSPSFSALKTALRQPLIFDGRNLYDPEIRSQGFDYLAIGR