Protein Info for ABID97_RS10325 in Variovorax sp. OAS795

Annotation: galactarate dehydratase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 535 TIGR03248: galactarate dehydratase" amino acids 18 to 535 (518 residues), 922.9 bits, see alignment E=2.2e-282 PF08666: SAF" amino acids 24 to 93 (70 residues), 27.3 bits, see alignment E=6.5e-10 PF04295: GD_AH_second" amino acids 124 to 282 (159 residues), 120.2 bits, see alignment E=1.1e-38 PF20629: GD_AH_C" amino acids 291 to 531 (241 residues), 302.6 bits, see alignment E=2.9e-94

Best Hits

KEGG orthology group: K01708, galactarate dehydratase [EC: 4.2.1.42] (inferred from 94% identity to vap:Vapar_1721)

Predicted SEED Role

"D-galactarate dehydratase (EC 4.2.1.42)" in subsystem D-Galacturonate and D-Glucuronate Utilization or D-galactarate, D-glucarate and D-glycerate catabolism (EC 4.2.1.42)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 4.2.1.42

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (535 amino acids)

>ABID97_RS10325 galactarate dehydratase (Variovorax sp. OAS795)
MADSSVSPSSAVRPPHRIHMHAADNVAIVANDGGLKAGAAFADGLVLVDNVPQGHKVALA
DLAEGDAVVRYNVVIGYALKAIPRGSWVHERLLRMPAARELEGLPIATVKPPAQPPLEGY
TFEGYRNLDGSVGTRNILAITQTVQCVAGVVDFAVQRIKAELLPKYPHVDDVVGLSHSYG
CGVAIDAPDAVIPIRTLRNISLNPNFGGEVMVISLGCEKLQPERLLPPGSIALVDERNVA
DIGETANARLDVVCLQDDAHVGFMSMIDSIMRQAEEHLERLNARRRETVPASELVVGVQC
GGSDAFSGVTANPAVGFCTDLLVRAGATVMFSEVTEVRDGIDQLTSRATTPEVAEAMIRE
MAWYDAYLDRGRVDRSANTTPGNKKGGLSNIVEKAMGSIVKSGSAPISGVVPPGEKARQK
GLLYTATPASDFICGTLQLAAGMTLHVFTTGRGTPYGLAEVPVIKVATRSDLARRWHDLM
DVNAGRIADGDATIEDVGWEMFRLMLDVASGRKKTWAEQWKLHNALVLFNPAPVT