Protein Info for ABID97_RS09515 in Variovorax sp. OAS795

Annotation: prephenate dehydratase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR01807: chorismate mutase
  • amino acids 18 to 91 (74 residues), 89.1 bits, E=9.1e-30
• PF01817: CM_2
  • amino acids 22 to 98 (77 residues), 73.4 bits, E=2.4e-24
• PF00800: PDT
  • amino acids 103 to 276 (174 residues), 191.2 bits, E=2.2e-60
• PF01842: ACT
  • amino acids 292 to 357 (66 residues), 32.4 bits, E=9.3e-12

Best Hits

KEGG orthology group: K14170, chorismate mutase / prephenate dehydratase [EC: 4.2.1.51 5.4.99.5] (inferred from 98% identity to vap:Vapar_1617)

Predicted SEED Role

"Chorismate mutase I (EC 5.4.99.5) / Prephenate dehydratase (EC 4.2.1.51)" in subsystem Chorismate Synthesis or Phenylalanine and Tyrosine Branches from Chorismate (EC 4.2.1.51, EC 5.4.99.5)

MetaCyc Pathways

• superpathway of aromatic amino acid biosynthesis (18/18 steps found)
• superpathway of L-phenylalanine biosynthesis (10/10 steps found)
• superpathway of L-tyrosine biosynthesis (10/10 steps found)
• L-phenylalanine biosynthesis I (3/3 steps found)
• L-tyrosine biosynthesis I (3/3 steps found)
• L-phenylalanine biosynthesis III (cytosolic, plants) (2/2 steps found)
• L-phenylalanine biosynthesis II (2/4 steps found)
• L-tyrosine biosynthesis III (2/4 steps found)
• superpathway of L-phenylalanine and L-tyrosine biosynthesis (2/5 steps found)
• L-tyrosine biosynthesis II (1/4 steps found)
• superpathway of chorismate metabolism (40/59 steps found)
• bacilysin biosynthesis (1/10 steps found)
• salinosporamide A biosynthesis (4/15 steps found)

KEGG Metabolic Maps

• Biosynthesis of alkaloids derived from shikimate pathway
• Biosynthesis of phenylpropanoids
• Phenylalanine, tyrosine and tryptophan biosynthesis

Isozymes

Compare fitness of predicted isozymes for: 4.2.1.51

Use Curated BLAST to search for 4.2.1.51 or 5.4.99.5

Protein Sequence (373 amino acids)

>ABID97_RS09515 prephenate dehydratase (Variovorax sp. OAS795)
MTASAPTPPSTPDNSESLSGLRVQIDSLDQRLLSLLNERAHVAELVGEVKKREGTPFFRP
DRVAQVIEKMQKSNAGPLKDLHVAAIWREIMSACLALESPQRVAVLGPEGTFCEQAAIEY
FGGAADLIYCASFDEVFHATAAGSAQYGVVGVENSTEGVVTRSLDLFLHSPTHVVGEVSL
LVRHHLLRSSNTLEGIEAVLAHPQALAQCQTWLSKHLPNAERRAVSSNAEGARLAATNPA
WAGLAGERAATRFGLHIVAHAIQDDSYNRTRFSVICLPQTLAMPPASGRDCTSLIVSVPN
RPGAVHDLLVPLKVNNVSMTRFESRPARTGQWEYYFYIDLDGHPSQPNVAAALAELRGLC
AFYKVLGAYPVKA