Protein Info for ABID97_RS08195 in Variovorax sp. OAS795
Annotation: histidine kinase
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
KEGG orthology group: K08082, two-component system, LytT family, sensor histidine kinase AlgZ [EC: 2.7.13.3] (inferred from 93% identity to vap:Vapar_1362)Predicted SEED Role
"Autolysis histidine kinase LytS" in subsystem Murein hydrolase regulation and cell death
Isozymes
Compare fitness of predicted isozymes for: 2.7.13.3
Use Curated BLAST to search for 2.7.13.3
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
Find the best match in UniProt
Protein Sequence (366 amino acids)
>ABID97_RS08195 histidine kinase (Variovorax sp. OAS795) MGWLPNVSLMRNPAILSASSTSTPSAPPERGRLPARGSAGLFDACQIGVVLRTVLFVEAV VATGTLFVSPSAGEWLVQTATVTGGALPATLLWLVAACGLRKPLGRLPRQAQYVAGAMLG AVSSLYGCGLLRLTGVVGSAPWVASAVAGGFIAALVMAAMVLRARGQTPAATTARLEELQ SRIQPHFLFNTLNSAIALVREEPAKAETMLEDLAELFRQALADPGESGTLADEIALAERY LAIEQVRFGDRLRIRWDLDAAASSARLPPLLLQPLVENAIKHGVEPSPEGAKLRIRTERR GSVVVIEVVNSLPPLRWADEPLPRGHGIALANVRDRLRLLHDMQMQFSAGMDQKNYRVRI AIPAEP