Protein Info for ABID97_RS07950 in Variovorax sp. OAS795

Annotation: acyl-CoA dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 775 PF02771: Acyl-CoA_dh_N" amino acids 9 to 103 (95 residues), 31.7 bits, see alignment E=3.6e-11 amino acids 399 to 507 (109 residues), 55.8 bits, see alignment E=1.1e-18 PF00441: Acyl-CoA_dh_1" amino acids 228 to 363 (136 residues), 66.8 bits, see alignment E=5e-22 amino acids 622 to 771 (150 residues), 46.6 bits, see alignment E=8.1e-16 PF08028: Acyl-CoA_dh_2" amino acids 237 to 340 (104 residues), 28.2 bits, see alignment E=4e-10 PF02770: Acyl-CoA_dh_M" amino acids 511 to 609 (99 residues), 74.1 bits, see alignment E=1.6e-24

Best Hits

KEGG orthology group: None (inferred from 93% identity to vap:Vapar_1314)

Predicted SEED Role

"Butyryl-CoA dehydrogenase (EC 1.3.99.2)" in subsystem Acetyl-CoA fermentation to Butyrate or Anaerobic respiratory reductases or Butanol Biosynthesis or Isobutyryl-CoA to Propionyl-CoA Module or Isoleucine degradation or Valine degradation (EC 1.3.99.2)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 1.3.99.2

Use Curated BLAST to search for 1.3.99.2

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (775 amino acids)

>ABID97_RS07950 acyl-CoA dehydrogenase (Variovorax sp. OAS795)
MDIESLSAMRDAALDYFVRSRSVQRRRERMERPDADEAQGWSAMAELGWTGMLAPESAGG
LGLDLAGAAQILRAAGEHVAPEPLLAVAGLSALLLARLGTPRAEALLADLVAGRSLPALA
WQESAGDLSAVPLSCGCEPRTGPAGGVLLQGEKLMVLPGAAASGWLVSARGSDDAVLLWV
PRGSEGVSETLVPLVDGGQAANLRFEQVALPADSVLGEGPAAQEALRHALAAGQVLQAAE
LLGVGQSMLAQTLAYLRTRTQFGKAIGSFQALQHRAVDMFIHLEVAQAALDEVLALAGQA
LSAERLEAEASRVNARCTAAALQASRAAVQLHGAIGYTQECDLSLYYKRTLCLAAWLGNA
AAHQRRHAALADVVDVRSSTAEWQGEFPRSADWAAMPEAEFRRMVRAFLQQRYPQQLRYL
SHRARWSEIRDWYLTLSGQGWIAAAWPQAHGGMGLPADKLIAWIEELEQHGVARAPDQGI
VMIGPLLIQHGTPEQQQRFLPRILSGEHVWCQGYSEPNAGSDLAGLRTEAVAGRDAEGDH
FIVNGQKIWTTLAQDANHIFMLVRTDKAARKQEGISFLLCDLRTPGVTVRPIHTLAGEPE
FCEVFFDNVRVPAENLVGRLHGGWTIAKALLGFERIFLGSPKQSQYALGQLARLAEARRL
FADPVFAQRFAALRLDVLDLSAAYTGFANIVRAGKPLPASVSLLKIWASETYHRIGALLV
EAGEEQGAVAGDQVLDGQSFNLLAPLIGSTAAMIYGGTNEIQRNILARQVLDLPT