Protein Info for ABID97_RS07940 in Variovorax sp. OAS795

Annotation: acyl-CoA dehydrogenase family protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 387 PF02771: Acyl-CoA_dh_N" amino acids 11 to 116 (106 residues), 89.1 bits, see alignment E=5.2e-29 PF02770: Acyl-CoA_dh_M" amino acids 121 to 219 (99 residues), 69.9 bits, see alignment E=3.6e-23 PF00441: Acyl-CoA_dh_1" amino acids 232 to 367 (136 residues), 117 bits, see alignment E=1.7e-37 PF08028: Acyl-CoA_dh_2" amino acids 249 to 360 (112 residues), 48.7 bits, see alignment E=1.9e-16

Best Hits

KEGG orthology group: K00249, acyl-CoA dehydrogenase [EC: 1.3.99.3] (inferred from 98% identity to vap:Vapar_1312)

Predicted SEED Role

"Probable acyl-CoA dehydrogenase (EC 1.3.99.3)" in subsystem Isoleucine degradation or Valine degradation (EC 1.3.99.3)

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 1.3.99.3

Use Curated BLAST to search for 1.3.99.3

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (387 amino acids)

>ABID97_RS07940 acyl-CoA dehydrogenase family protein (Variovorax sp. OAS795)
MNNSNDTRFADIRDAVRDLCAQFPNEYFRKVDEARGYPAEFVDALTKAGWMAALIPQEYG
GSGLGLTEASVIMEEINRCGGNSGACHGQMYNMGTLLRHGSEAQKRNYLPRIATGELRLQ
SMGVTEPSTGTDTTKIKTTAVKKGDRYVVNGQKVWISRIQHSDLMILLARTTPLADVKKK
SEGMSIFIVDLREAIGHGMTVRPILNMVNHETNELFFENLEIPAENLIGEEGQGFKYILD
GLNAERTLIAAECIGDGHWFIDRVTAYTKERVVFGRPIGQNQGVQFPIAEAFIEIEAANL
MRYEACRLFDAREPCGAQANMAKYLAAKASWEAANACLQFHGGFGFACEYDIERKFRETR
LYQVAPISTNLILSYVAEHMLGLPRSF