Protein Info for ABID97_RS07630 in Variovorax sp. OAS795

Annotation: cytochrome o ubiquinol oxidase subunit III

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00510: COX3
  • amino acids 38 to 218 (181 residues), 59.4 bits, E=2.6e-20
• TIGR02842: cytochrome o ubiquinol oxidase, subunit III
  • amino acids 41 to 219 (179 residues), 274.9 bits, E=2e-86

Best Hits

Swiss-Prot: 60% identical to CYOC_SHIFL: Cytochrome bo(3) ubiquinol oxidase subunit 3 (cyoC) from Shigella flexneri

KEGG orthology group: K02299, cytochrome o ubiquinol oxidase subunit III [EC: 1.10.3.-] (inferred from 98% identity to vap:Vapar_4048)

MetaCyc: 60% identical to cytochrome bo3 subunit 3 (Escherichia coli K-12 substr. MG1655)
RXN-21817 [EC: 7.1.1.3]

Predicted SEED Role

"Cytochrome O ubiquinol oxidase subunit III (EC 1.10.3.-)" in subsystem Terminal cytochrome O ubiquinol oxidase or Terminal cytochrome oxidases (EC 1.10.3.-)

MetaCyc Pathways

• NADH to cytochrome bo oxidase electron transfer I (2/2 steps found)
• NADH to cytochrome bo oxidase electron transfer II (2/2 steps found)
• glycerol-3-phosphate to cytochrome bo oxidase electron transfer (2/2 steps found)
• pyruvate to cytochrome bo oxidase electron transfer (2/2 steps found)
• succinate to cytochrome bo oxidase electron transfer (2/2 steps found)
• D-lactate to cytochrome bo oxidase electron transfer (1/2 steps found)
• proline to cytochrome bo oxidase electron transfer (1/2 steps found)

Isozymes

Compare fitness of predicted isozymes for: 1.10.3.-

Use Curated BLAST to search for 1.10.3.- or 7.1.1.3

Protein Sequence (221 amino acids)

>ABID97_RS07630 cytochrome o ubiquinol oxidase subunit III (Variovorax sp. OAS795)
MSDTTALHAPAAGHAHSDHTGKPPVFELFHVGNDHHPENGTLLGFWLYLMSDCLVFACLF
AVYGVLGRSYAAGPSGADLFDLPLVAINTSLLLFSSITYGFAVLEMQRKRMGGTLAWLAI
TGLLGAGFIGLELYEFAHLIHEGAGPQRSAFLSSFFALVGTHGLHVTFGIVWLIVLMVQL
PKHGFTAANRRRLMCLSMFWHFLDVVWIGVFTFVYLMGSMA