Protein Info for ABID97_RS07415 in Variovorax sp. OAS795

Annotation: quinolinate synthase NadA

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR00550: quinolinate synthetase complex, A subunit
  • amino acids 42 to 353 (312 residues), 344.5 bits, E=2.7e-107
• PF02445: NadA
  • amino acids 45 to 350 (306 residues), 341.7 bits, E=1.7e-106

Best Hits

Swiss-Prot: 68% identical to NADA_HERAR: Quinolinate synthase A (nadA) from Herminiimonas arsenicoxydans

KEGG orthology group: K03517, quinolinate synthase [EC: 2.5.1.72] (inferred from 92% identity to vpe:Varpa_4764)

MetaCyc: 61% identical to quinolinate synthase (Escherichia coli K-12 substr. MG1655)
Quinolinate synthase. [EC: 2.5.1.72]

Predicted SEED Role

"Quinolinate synthetase (EC 2.5.1.72)" in subsystem NAD and NADP cofactor biosynthesis global or NAD regulation (EC 2.5.1.72)

MetaCyc Pathways

• aspartate superpathway (24/25 steps found)
• NAD de novo biosynthesis I (6/6 steps found)
• NAD de novo biosynthesis III (5/6 steps found)
• NAD de novo biosynthesis IV (anaerobic) (5/6 steps found)
• nicotine biosynthesis (3/9 steps found)
• superpathway of nicotine biosynthesis (4/12 steps found)

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.5.1.72

Protein Sequence (372 amino acids)

>ABID97_RS07415 quinolinate synthase NadA (Variovorax sp. OAS795)
MATASIIDVDYEQPASQGSACDTRHAWARVPPEPSADERIALKARIRRLLRERNAVMVSH
FYVHPDLQDLAEETGGIVSDSLEMARFGRDHAATTLVVSGVRFMGETAKILSPEKRVLMP
DLDANCSLDLGCPVDQFSAFCDRHPDRTVVVYANTSAAVKARADWLVTSSCALDVVGALH
AQGRKILWGPDRHLGDYIQRQTGADMVSWNGACIVHDEFKALELDLLMKAHPSAKVLVHP
ESPADVIALADAVGSTSAILNAARRMDANEFIVATDTGMLHKLRTLNPGKTFIEAPTAGN
GGTCKSCAHCPWMAMNGLVELANALETGAGEIHVDPALGLRARVPIDRMLAFTAGLKNGQ
PAGSLIAGIGAA