Protein Info for ABID97_RS07405 in Variovorax sp. OAS795

Annotation: NAD(P)H-dependent glycerol-3-phosphate dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF01210: NAD_Gly3P_dh_N
  • amino acids 2 to 159 (158 residues), 121.3 bits, E=7.5e-39
• PF02558: ApbA
  • amino acids 3 to 95 (93 residues), 25.2 bits, E=2.2e-09
• PF07479: NAD_Gly3P_dh_C
  • amino acids 181 to 321 (141 residues), 177.6 bits, E=3.3e-56
• PF20618: GPD_NAD_C_bact
  • amino acids 241 to 307 (67 residues), 75.8 bits, E=6.2e-25

Best Hits

Swiss-Prot: 91% identical to GPDA_VARPS: Glycerol-3-phosphate dehydrogenase [NAD(P)+] (gpsA) from Variovorax paradoxus (strain S110)

KEGG orthology group: K00057, glycerol-3-phosphate dehydrogenase (NAD(P)+) [EC: 1.1.1.94] (inferred from 91% identity to vap:Vapar_4099)

Predicted SEED Role

"Glycerol-3-phosphate dehydrogenase [NAD(P)+] (EC 1.1.1.94)" in subsystem Glycerol and Glycerol-3-phosphate Uptake and Utilization or Glycerolipid and Glycerophospholipid Metabolism in Bacteria (EC 1.1.1.94)

MetaCyc Pathways

• superpathway of phospholipid biosynthesis III (E. coli) (11/12 steps found)
• phosphatidylglycerol biosynthesis I (6/6 steps found)
• phosphatidylglycerol biosynthesis II (6/6 steps found)
• CDP-diacylglycerol biosynthesis I (4/4 steps found)
• CDP-diacylglycerol biosynthesis II (4/4 steps found)
• superpathway of cardiolipin biosynthesis (bacteria) (10/13 steps found)
• glycerol-3-phosphate shuttle (2/2 steps found)
• CDP-diacylglycerol biosynthesis III (3/5 steps found)
• glucosylglycerol biosynthesis (3/5 steps found)
• phosphatidate biosynthesis (yeast) (3/5 steps found)
• 1,3-propanediol biosynthesis (engineered) (5/9 steps found)
• superpathway of phospholipid biosynthesis II (plants) (10/28 steps found)

KEGG Metabolic Maps

• Glycerophospholipid metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.1.1.94

Protein Sequence (345 amino acids)

>ABID97_RS07405 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase (Variovorax sp. OAS795)
MKICVHGAGAWGTALAANAAGRHEVTLWARDASQADAISKARENIRYLPGLALPAALAVR
AGDLRQAQAGAELVIVATPMAALRQQLTDLRGTTAPVAWLCKGVEPARGQSPNAFGLLAH
EIWAQVAPELRAGVLSGPSFAQEVAEGRPTALVAASPHPAVRDALVDAFHGPALRVYAND
DIVGVEVGGAVKNVLAIATGLCDGLALGLNARAALITRGLAEMTRFGLALGARAETFMGL
SGLGDLVLTSTGDLSRNRKVGLLLAQGRTLAEAVASLGHVAEGVYCARTVVQRARGLGVE
MPIAEGVVALLDGKLSPHEAVASLTGRDPVPESLRSPSDPHDQTP