Protein Info for ABID97_RS07375 in Variovorax sp. OAS795

Annotation: molybdopterin-synthase adenylyltransferase MoeB

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

Best Hits

Swiss-Prot: 47% identical to UBAA_HALVD: SAMP-activating enzyme E1 (ubaA) from Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2)

KEGG orthology group: None (inferred from 91% identity to vpe:Varpa_4772)

MetaCyc: 47% identical to E1 SAMP-activating enzyme monomer (Haloferax volcanii)
RXN-18690 [EC: 6.2.1.55]; RXN-18689 [EC: 6.2.1.55, 2.7.7.100]; 2.3.2.- [EC: 6.2.1.55, 2.7.7.100]

Predicted SEED Role

"Sulfur carrier protein adenylyltransferase ThiF" in subsystem Thiamin biosynthesis

MetaCyc Pathways

superpathway of thiamine diphosphate biosynthesis II (9/11 steps found)
thiazole component of thiamine diphosphate biosynthesis II (5/7 steps found)
superpathway of thiamine diphosphate biosynthesis I (7/10 steps found)
protein SAMPylation and SAMP-mediated thiolation (3/6 steps found)
thiazole component of thiamine diphosphate biosynthesis I (3/6 steps found)

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.7.7.100 or 6.2.1.55

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (253 amino acids)

>ABID97_RS07375 molybdopterin-synthase adenylyltransferase MoeB (Variovorax sp. OAS795)
MDDHDLLRYSRHILLEEFGIDGQTRVSAGRALVIGAGGLGSPVALYLAAAGVGHVTLVDD
DEVDLTNLQRQVAHTHARVGRLKVESAAEAMRGINPGISIETHAQRADEQLLSRLVAAVD
VVVDCCDNFATRHAVNRACVAHGKPLVAGAAIRFDGQLSVYDTRDPASPCYACIFPPDAA
FEETLCAVLGVFGPVVGTIGTLQASEALKLLAGIGPSLAGKLLMFDGRRTAFDTLKIARD
PHCAVCAERTTGA