Protein Info for ABID97_RS06745 in Variovorax sp. OAS795

Annotation: ATP-dependent DNA helicase RecQ

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 587 TIGR00614: ATP-dependent DNA helicase, RecQ family" amino acids 22 to 358 (337 residues), 356.6 bits, see alignment E=1e-110 PF04851: ResIII" amino acids 32 to 191 (160 residues), 37.4 bits, see alignment E=4.8e-13 PF00270: DEAD" amino acids 34 to 195 (162 residues), 94.4 bits, see alignment E=1.4e-30 PF00271: Helicase_C" amino acids 242 to 339 (98 residues), 71 bits, see alignment E=2e-23 PF16124: RecQ_Zn_bind" amino acids 444 to 492 (49 residues), 36 bits, see alignment 1.9e-12

Best Hits

KEGG orthology group: K03654, ATP-dependent DNA helicase RecQ [EC: 3.6.4.12] (inferred from 81% identity to vap:Vapar_6295)

Predicted SEED Role

"ATP-dependent DNA helicase RecQ" in subsystem DNA-replication or DNA repair, bacterial RecFOR pathway

Isozymes

Compare fitness of predicted isozymes for: 3.6.4.12

Use Curated BLAST to search for 3.6.4.12

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (587 amino acids)

>ABID97_RS06745 ATP-dependent DNA helicase RecQ (Variovorax sp. OAS795)
MRSPARKAHGRTNPAASEVDRVLREVFGHERLRPGQRPVIDRVVAGQSALAVMPTGAGKS
LCYQVPAVLAPGQTVVVSPLIALMKDQCEKLDANGVRAVQLNSQCTAEEIDAAEKAIADG
SARVIFSTPERLADAAFLKLLQQRPTSLLVVDEAHCISQWGHDFRPAFLEIGAAVRALRK
PVVLALTATANDEVAEEIMEKLGIPRAGLIDTGAYRPNLHYAVEPAMREQDKLQRALALV
AGLQGSGIVYTATVKAAEALFAELAGTGASVGLYHGKLRAAERRDAQDAFMAGKLRVMVA
TNAFGMGIDKPDIRFVLHYQMPSSLDAYYQETGRAGRDGKRADCVLLYLRRDKAVQQFFL
AGWLPEAAELRALQQVLSGAPPEERAGWQAAELQQRAHLPRGKLRVLLSLLRQEGLVERD
SDGALRWGKRPPLEDAELDALLQGHREKREQDREALERMTFYATTGMCRWQVLLSSLGSD
ELAQRCGACDNCVRLARHERARAAQSTVEEADADRAPAPREVFARGASVRVPRYGVGSVA
SADAVSVTIEFADGSQRCFQPEYVSPVPARRTRRTVQRLVTAPAGQR