Protein Info for ABID97_RS06185 in Variovorax sp. OAS795

Annotation: ATP-dependent protease ATPase subunit HslU

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 442 TIGR00390: ATP-dependent protease HslVU, ATPase subunit" amino acids 3 to 442 (440 residues), 666.8 bits, see alignment E=8.2e-205 PF07728: AAA_5" amino acids 51 to 87 (37 residues), 22.7 bits, see alignment 2.5e-08 PF00004: AAA" amino acids 52 to 101 (50 residues), 29.1 bits, see alignment 3.7e-10 amino acids 231 to 331 (101 residues), 31.8 bits, see alignment E=5.4e-11 PF07724: AAA_2" amino acids 184 to 328 (145 residues), 97.4 bits, see alignment E=2.9e-31

Best Hits

Swiss-Prot: 81% identical to HSLU_ACISJ: ATP-dependent protease ATPase subunit HslU (hslU) from Acidovorax sp. (strain JS42)

KEGG orthology group: K03667, ATP-dependent HslUV protease ATP-binding subunit HslU (inferred from 98% identity to vap:Vapar_0909)

Predicted SEED Role

"ATP-dependent hsl protease ATP-binding subunit HslU" in subsystem Proteasome bacterial or Proteolysis in bacteria, ATP-dependent

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (442 amino acids)

>ABID97_RS06185 ATP-dependent protease ATPase subunit HslU (Variovorax sp. OAS795)
MSMTPQEIVSELDNHIVGQPAAKRAVAIALRNRWRRQQVEEKLRTEITPKNILMIGPTGV
GKTEIARRLARLADAPFIKVEATKFTEVGYVGKDVDSIIRDLAEIAVKQTREAESAKVRA
RAEDAAEDRILDVLLPPARGADTGAPALDGPNPTRQAFRKKLREHQLDDKEIELDLAEAR
APLEIMGPAGMEEMTEQLRGMFGQLGGGKRKTRKLKIAEAMRLLIDEEAAKLVNEDEIRA
QAITNAEQNGIVFIDEIDKVATRSEAQGSDVSRQGVQRDLLPLVEGTAVSTKYGVVRTDH
MLFIASGAFHLSKPSDLIPELQGRFPIRVELQSLSVSDFESILTQTRASLVKQYQALLAT
EGVTLEFTPEGVNRLAAIAFEVNERTENIGARRLSTVMERLLDEVSFDATRIEGQTIHID
AAYVDERLAALSHDEDLSRFIL