Protein Info for ABID97_RS05480 in Variovorax sp. OAS795

Annotation: EAL domain-containing protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 850 900 950 990 transmembrane" amino acids 12 to 33 (22 residues), see Phobius details amino acids 288 to 308 (21 residues), see Phobius details PF12860: PAS_7" amino acids 332 to 384 (53 residues), 32.7 bits, see alignment 1.8e-11 amino acids 384 to 424 (41 residues), 27.8 bits, see alignment (E = 6.2e-10) TIGR00254: diguanylate cyclase (GGDEF) domain" amino acids 553 to 721 (169 residues), 124.9 bits, see alignment E=2.7e-40 PF00990: GGDEF" amino acids 557 to 718 (162 residues), 149 bits, see alignment E=2.7e-47 PF00563: EAL" amino acids 741 to 974 (234 residues), 228.4 bits, see alignment E=2.2e-71

Best Hits

KEGG orthology group: None (inferred from 81% identity to vap:Vapar_0715)

Predicted SEED Role

"diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(s)" in subsystem Bacterial hemoglobins

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (990 amino acids)

>ABID97_RS05480 EAL domain-containing protein (Variovorax sp. OAS795)
MNKPLPRRITAFVYGVAALFLGAVLSIAALTMWQTHEKAIAESEGEARRFVGASEAALNR
GLLGVDMLLAGMGQFLRKSTESSVAQDIAQPDNAQLMETIVRQSLLVRYLAFLDTEGNVV
ASSDRRGARLAVQLPEGFLKELLGRQGSVLAISAPSVSLATSQQVLYFGRVLRLSDGSRL
VAVAEVQVSMLTTILAQGASVKGLEVTLERDAGPLLASTPPRDDLAGRIIQPPVTDQIGD
GHPRRMAARLSGTPAIVVARPTLYRNLLIVASIPLEVALEDWRRERDLILGTALAFTLMI
LAISYFAHLQLRRQWRARGDLLRSKATLDQALESMADGFVLLDPEGRIVTWNRRFVDYFP
WTETLLSPSATFQQIDDQNVRHLHAQNEQELTLPNGQVILAVKSPTPDGGLVCVYRDVTE
KRRHLADILEGKAQLQATLDALPDVLLEAGIDGRCHSFHSPRRPRSSLKVREPVGKLMSE
LLPAAAAAEVMVALRDAFEFGFSSGRQFESRGPKGALWFEISVSRKALGEGADARFIVIL
RNITDSKLAAREIEHLAFYDILTGLPNRRLLLHRLQASIDANIRRSRHGALLFLDLDDFK
TLNDALGHAVGDELLKQVAVRLQASLGEGSTVARLGGDEFVVLLENLGEDPAVAAMQTNA
SGEAILAGLNQAFQLDNHQYHSTCSIGAVVFAATHQSLEDLLKQADIAMYYAKSAGGNAL
RFFEAAMQTAITARATLESEMHAALEGGQFVLHYQSQVTSEGHIVGAEVLIRWHHPVKGM
VQPGGFIELAEETGLIVPIGMWVLETACVQLERWSHDPRRRHLQLAVNVSARQFRTDDFA
ERVFDVIRRTGADPTRLKLELTESLLQDKVTETIGKMQSLAAKGIHFSMDDFGTGYSSLS
YMTQLPLNQIKVDKFFVQNIGVDPKVELIIQAIIGMARNLDLEIVAEGVETQQQFEFLQA
HGAMLCQGYLFSRPVPIDQFEAQLDVAMAD