Protein Info for ABID97_RS03435 in Variovorax sp. OAS795

Annotation: imidazolonepropionase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 408 TIGR01224: imidazolonepropionase" amino acids 26 to 402 (377 residues), 472.5 bits, see alignment E=4.2e-146 PF01979: Amidohydro_1" amino acids 61 to 402 (342 residues), 63.1 bits, see alignment E=2.9e-21 PF07969: Amidohydro_3" amino acids 217 to 403 (187 residues), 53.3 bits, see alignment E=3.4e-18

Best Hits

Swiss-Prot: 83% identical to HUTI_POLSJ: Imidazolonepropionase (hutI) from Polaromonas sp. (strain JS666 / ATCC BAA-500)

KEGG orthology group: K01468, imidazolonepropionase [EC: 3.5.2.7] (inferred from 91% identity to vpe:Varpa_0190)

MetaCyc: 62% identical to imidazolonepropionase (Pseudomonas fluorescens)
Imidazolonepropionase. [EC: 3.5.2.7]

Predicted SEED Role

"Imidazolonepropionase (EC 3.5.2.7)" in subsystem Histidine Degradation (EC 3.5.2.7)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.5.2.7

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (408 amino acids)

>ABID97_RS03435 imidazolonepropionase (Variovorax sp. OAS795)
MNPTHEHPSADGLWTGLRLATDPGTEAAIVVSEGTVRWVGARDALPSGFAGFPPHDGGGA
LVTPGLVDCHTHLVYGGQRANEFAMRLAGATYEEVAKAGGGIVSSVRATREADEDTLFAQ
AAPRLEQLLADGVCAIEIKSGYGLSLEHERKQLRVARRLGEAYGVTVRTTFLGAHALPPE
YAGRSGDYIALVCNQMLPALAAEGLVDAVDVFCERIAFSLVETEQVFKAAKALGLPVKLH
AEQLSDMGGAALAARYGALSCDHIEHLSAEGIEAMREAGTVAVLLPGAYYTLRDTHLPPI
QALRTAGVPMAVSTDHNPGTSPALSLLLMMNMACTLFRLTVPEALAGVTVHAARALGLQE
THGAIAEGMPANFVLWNVRDAAELAYWFGQRPVRSVVRQGRIAVGAAA