Protein Info for ABID97_RS03415 in Variovorax sp. OAS795

Annotation: histidine utilization repressor

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 245 TIGR02018: histidine utilization repressor" amino acids 10 to 237 (228 residues), 307.4 bits, see alignment E=2.7e-96 PF00392: GntR" amino acids 10 to 73 (64 residues), 69.1 bits, see alignment E=3.2e-23 PF08220: HTH_DeoR" amino acids 38 to 68 (31 residues), 23.6 bits, see alignment 5.2e-09 PF07702: UTRA" amino acids 94 to 230 (137 residues), 127.1 bits, see alignment E=7.1e-41

Best Hits

Swiss-Prot: 52% identical to HUTC_PSEAE: Histidine utilization repressor (hutC) from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)

KEGG orthology group: K05836, GntR family transcriptional regulator, histidine utilization repressor (inferred from 98% identity to vap:Vapar_0157)

Predicted SEED Role

"Histidine utilization repressor" in subsystem Histidine Degradation

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (245 amino acids)

>ABID97_RS03415 histidine utilization repressor (Variovorax sp. OAS795)
MKRDLPSLALYAQVKDHISRKIQDGTWPAGHRLPSESELVAQFGISRMTVNRALRELMEQ
GRIVRVAGVGSFVAENKPQSTLLQIANIASEIRQRGHDYRCEMLAVERVAASPDVAAWLD
MRAGTSVFHSVCLHLENDTPVQLEERYVNPQVVPDFLEQDFAAVPPSEYLVRNVPFDQIE
HVVDAVLPTAEQASRLAMEPTDPCLLLTRRTWTRNTPVTWVRCLHPASRYSLGSRFKADG
NPSFG