Protein Info for ABID97_RS03185 in Variovorax sp. OAS795

Annotation: adenylate/guanylate cyclase domain-containing protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 605 signal peptide" amino acids 1 to 23 (23 residues), see Phobius details transmembrane" amino acids 320 to 340 (21 residues), see Phobius details PF02743: dCache_1" amino acids 41 to 305 (265 residues), 49.4 bits, see alignment E=4.4e-17 PF00211: Guanylate_cyc" amino acids 421 to 601 (181 residues), 102.1 bits, see alignment E=2.9e-33

Best Hits

KEGG orthology group: K01768, adenylate cyclase [EC: 4.6.1.1] (inferred from 76% identity to vpe:Varpa_0124)

Predicted SEED Role

"Adenylate cyclase (EC 4.6.1.1)" in subsystem cAMP signaling in bacteria (EC 4.6.1.1)

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 4.6.1.1

Use Curated BLAST to search for 4.6.1.1

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (605 amino acids)

>ABID97_RS03185 adenylate/guanylate cyclase domain-containing protein (Variovorax sp. OAS795)
MSAVALSQSLLLVGLGYWGSQRLVSDIGRSAHKANHDRTEDKVLAFLAKTESVVGALGDS
PTLRPTGPSADQTAELLWTLLQQSPELDSTYVADDEGQMLMVLRYPAPAVRRISRGPSFT
TETWEFKPPSSVQDDARHRYATTRIEARRSSYDPAQRSWYIGARKANGPVWTQPYVFAAA
QELGVTYALPSRRTQADGASRTLVVAGDVSLGRLSEFVRLFSSSSGQGNSALLSASHQVL
ARSDVPGVVRQLMPAKDGVLGALSDHLLSDGAADGPPETSFSMAYGGRRYLVQTSRIPST
GWELVSWVPEDMLLGALQRAVLWGLLLAVLFLAATLLLSLRLSKLVTSPVENLSHIARRI
GLLELDNLPREHSRVLEIQHLDQALDESARSLKAFSKFVPVDVINRLIAEGHALAPSGSP
RRITVMFTDVEGFTSISESIPADVLVGLLTEYFNVAARVIAQHGGVIDKFIGDGIMVLWG
APADLQDAEYQACTAALQLHAEMAALNGRWRAQGLPEFRTRIGIHTGVVIAGVLGSNDRL
AYTAFGDVINVASRIEGINKQLNTQTLVSEATFEALGGRLRTRRIEEDAELRGRQTRMVL
YELLA