Protein Info for ABI39_RS20925 in Phocaeicola dorei CL03T12C01

Annotation: threonine--tRNA ligase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 646 PF02824: TGS" amino acids 2 to 55 (54 residues), 35.7 bits, see alignment 1.5e-12 TIGR00418: threonine--tRNA ligase" amino acids 72 to 638 (567 residues), 708.8 bits, see alignment E=3.3e-217 PF07973: tRNA_SAD" amino acids 169 to 218 (50 residues), 48.4 bits, see alignment 1.5e-16 PF00587: tRNA-synt_2b" amino acids 325 to 535 (211 residues), 157.9 bits, see alignment E=5.9e-50 PF03129: HGTP_anticodon" amino acids 548 to 637 (90 residues), 91.1 bits, see alignment E=8.4e-30

Best Hits

Swiss-Prot: 100% identical to SYT_BACV8: Threonine--tRNA ligase (thrS) from Bacteroides vulgatus (strain ATCC 8482 / DSM 1447 / JCM 5826 / NBRC 14291 / NCTC 11154)

KEGG orthology group: K01868, threonyl-tRNA synthetase [EC: 6.1.1.3] (inferred from 100% identity to bvu:BVU_4059)

Predicted SEED Role

"Threonyl-tRNA synthetase (EC 6.1.1.3)" (EC 6.1.1.3)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 6.1.1.3

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (646 amino acids)

>ABI39_RS20925 threonine--tRNA ligase (Phocaeicola dorei CL03T12C01)
MIKITFPDGSVREYNEGVTGLQIAESISSRLAQDVLACGVNGETIDLSRPINEDANFVLY
KWEDEQGKHAFWHTSAHLLAEALQELYPGIQFGIGPAIENGFYYDVDPGEAIIKEADLPA
IEAKMAELAAKKEILVRQSIAKEDALKKFGERGETYKCELISELEDGHITTYTQGAFTDL
CRGPHLTSTAPIKAIKLLSVAGAYWRGQEDRKQMTRIYGITFPKKKMLDEYLVMLEEAKK
RDHRKIGKEMDLFMFTDMVGKGLPMWLPKGTALRIRLQDFLRRIQARYDYQEVMCPPIGN
KNLYITSGHYAKYGKDSFQPIHTPEEGEEYFLKPMNCPHHCMIYKNSPRSYKDLPLRIAE
FGTVCRYEQSGELHGLTRVRSFTQDDAHLFCRPDQVKEEFLRVMDIINIVFKSMNFENVE
AQISLRDKVNREKYIGSDENWEKAEQAIIEACEEKGLTAKVEYGEAAFYGPKLDFMVKDA
IGRRWQLGTIQVDYNLPERFQLEYMGSDNQKHRPVMIHRAPFGSMERFVAVLIEHTAGKF
PLWLTPDQVAILPISEKFNEYAEKVKAELRKFDVRAIVDDRNEKIGRKIRDNEMKRIPYM
LIVGEKEAENGEVAVRKQGEGDKGTMKIEEFGKNIAEEVSNMINKW