Protein Info for ABI39_RS17975 in Phocaeicola dorei CL03T12C01

Annotation: type I glyceraldehyde-3-phosphate dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00044: Gp_dh_N
  • amino acids 2 to 104 (103 residues), 130.4 bits, E=2.9e-42
• TIGR01534: glyceraldehyde-3-phosphate dehydrogenase, type I
  • amino acids 3 to 326 (324 residues), 443.1 bits, E=3.1e-137
• PF02800: Gp_dh_C
  • amino acids 157 to 314 (158 residues), 231.7 bits, E=3.3e-73

Best Hits

Swiss-Prot: 73% identical to G3P_ESCF3: Glyceraldehyde-3-phosphate dehydrogenase (gapA) from Escherichia fergusonii (strain ATCC 35469 / DSM 13698 / CDC 0568-73)

KEGG orthology group: K00134, glyceraldehyde 3-phosphate dehydrogenase [EC: 1.2.1.12] (inferred from 100% identity to bvu:BVU_3585)

MetaCyc: 74% identical to glyceraldehyde-3-phosphate dehydrogenase A (Escherichia coli K-12 substr. MG1655)
Glyceraldehyde-3-phosphate dehydrogenase (phosphorylating). [EC: 1.2.1.12]

Predicted SEED Role

"NAD-dependent glyceraldehyde-3-phosphate dehydrogenase (EC 1.2.1.12)" in subsystem Calvin-Benson cycle or Entner-Doudoroff Pathway or Glycolysis and Gluconeogenesis or Pyridoxin (Vitamin B6) Biosynthesis or Redox-dependent regulation of nucleus processes (EC 1.2.1.12)

MetaCyc Pathways

• superpathway of glucose and xylose degradation (16/17 steps found)
• superpathway of pyridoxal 5'-phosphate biosynthesis and salvage (11/12 steps found)
• glycolysis III (from glucose) (10/11 steps found)
• pyridoxal 5'-phosphate biosynthesis I (7/7 steps found)
• Entner-Doudoroff pathway I (8/9 steps found)
• homolactic fermentation (10/12 steps found)
• Bifidobacterium shunt (12/15 steps found)
• glycolysis II (from fructose 6-phosphate) (9/11 steps found)
• heterolactic fermentation (14/18 steps found)
• glycolysis IV (8/10 steps found)
• superpathway of glycolysis and the Entner-Doudoroff pathway (13/17 steps found)
• gluconeogenesis I (10/13 steps found)
• glycolysis I (from glucose 6-phosphate) (10/13 steps found)
• formaldehyde assimilation III (dihydroxyacetone cycle) (9/12 steps found)
• gluconeogenesis III (9/12 steps found)
• superpathway of N-acetylneuraminate degradation (16/22 steps found)
• sucrose biosynthesis I (from photosynthesis) (6/9 steps found)
• hexitol fermentation to lactate, formate, ethanol and acetate (13/19 steps found)
• superpathway of anaerobic sucrose degradation (13/19 steps found)
• superpathway of cytosolic glycolysis (plants), pyruvate dehydrogenase and TCA cycle (15/22 steps found)
• glycolysis VI (from fructose) (7/11 steps found)
• superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass (17/26 steps found)
• superpathway of hexitol degradation (bacteria) (11/18 steps found)
• glycerol degradation to butanol (7/16 steps found)

KEGG Metabolic Maps

• Biosynthesis of alkaloids derived from histidine and purine
• Biosynthesis of alkaloids derived from ornithine, lysine and nicotinic acid
• Biosynthesis of alkaloids derived from shikimate pathway
• Biosynthesis of alkaloids derived from terpenoid and polyketide
• Biosynthesis of phenylpropanoids
• Biosynthesis of plant hormones
• Biosynthesis of terpenoids and steroids
• Glycolysis / Gluconeogenesis

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.2.1.12

Protein Sequence (336 amino acids)

>ABI39_RS17975 type I glyceraldehyde-3-phosphate dehydrogenase (Phocaeicola dorei CL03T12C01)
MIKVGINGFGRIGRFVFRAAQKRNDIQIVGINDLCPVDYLAYMLKYDTMHGQFDGTIEAD
VENSKLIVNGNAIRVTAERNPADLKWDAIGAEYVVESTGLFLTKEKAQAHIEAGAKYVVM
SAPSKDDTPMFVCGVNEKTYVKGTQFVSNASCTTNCLAPIAKVLNDKWGITDGLMTTVHS
TTATQKTVDGPSMKDWRGGRAASGNIIPSSTGAAKAVGKVIPELNGKLTGMSMRVPTLDV
SVVDLTVNLAKPATYAEICAAMKEASEGELAGVLGYTEDAVVSSDFLGDTRTSIFDAKAG
IALTDTFVKVVSWYDNEIGYSNKVLDLIAHMASVNC