Protein Info for ABI39_RS17345 in Phocaeicola dorei CL03T12C01

Annotation: 3-deoxy-manno-octulosonate cytidylyltransferase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 252 TIGR00466: 3-deoxy-D-manno-octulosonate cytidylyltransferase" amino acids 1 to 239 (239 residues), 216.3 bits, see alignment E=2.1e-68 PF02348: CTP_transf_3" amino acids 4 to 221 (218 residues), 184.2 bits, see alignment E=3e-58 PF12804: NTP_transf_3" amino acids 18 to 151 (134 residues), 40.1 bits, see alignment E=4.3e-14

Best Hits

Swiss-Prot: 95% identical to KDSB_BACV8: 3-deoxy-manno-octulosonate cytidylyltransferase (kdsB) from Bacteroides vulgatus (strain ATCC 8482 / DSM 1447 / JCM 5826 / NBRC 14291 / NCTC 11154)

KEGG orthology group: K00979, 3-deoxy-manno-octulosonate cytidylyltransferase (CMP-KDO synthetase) [EC: 2.7.7.38] (inferred from 95% identity to bvu:BVU_3328)

Predicted SEED Role

"3-deoxy-manno-octulosonate cytidylyltransferase (EC 2.7.7.38)" in subsystem KDO2-Lipid A biosynthesis (EC 2.7.7.38)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.7.7.38

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (252 amino acids)

>ABI39_RS17345 3-deoxy-manno-octulosonate cytidylyltransferase (Phocaeicola dorei CL03T12C01)
MKFIGIIPARYASTRFPAKPLAILGGKPVIQRVYEQVAGILDEAYVATDDERIESAVKAF
GGKVVMTSVHHKSGTDRCYEAYTKVGQGYDVVVNIQGDEPFIQRSQLEAVKACFEDSATQ
IATLVKPFTPEDGFEALENVNSPKVVVNKNMNALYFSRSVIPFQRNAEKEGWLKEHTYYK
HIGLYAYRADVLKEITSLPQSSLELAESLEQLRWLENGYTIKVGISEVETIGIDTPQDLA
RAEAFLKQREGK