Protein Info for ABI39_RS15035 in Phocaeicola dorei CL03T12C01

Annotation: 2-aminoethylphosphonate--pyruvate transaminase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR02326: 2-aminoethylphosphonate--pyruvate transaminase
  • amino acids 2 to 360 (359 residues), 575 bits, E=6.6e-177
• TIGR03301: 2-aminoethylphosphonate aminotransferase
  • amino acids 5 to 360 (356 residues), 510.2 bits, E=3.5e-157
• PF00266: Aminotran_5
  • amino acids 36 to 330 (295 residues), 83.1 bits, E=1e-27

Best Hits

Swiss-Prot: 99% identical to PHNW_BACV8: 2-aminoethylphosphonate--pyruvate transaminase (phnW) from Bacteroides vulgatus (strain ATCC 8482 / DSM 1447 / JCM 5826 / NBRC 14291 / NCTC 11154)

KEGG orthology group: K03430, 2-aminoethylphosphonate-pyruvate transaminase [EC: 2.6.1.37] (inferred from 99% identity to bvu:BVU_3006)

MetaCyc: 44% identical to 2-aminoethylphosphonate aminotransferase monomer (Pseudomonas aeruginosa)
2-aminoethylphosphonate--pyruvate transaminase. [EC: 2.6.1.37]

Predicted SEED Role

"2-aminoethylphosphonate:pyruvate aminotransferase (EC 2.6.1.37)" in subsystem Phosphonate metabolism (EC 2.6.1.37)

MetaCyc Pathways

• 2-aminoethylphosphonate degradation I (2/3 steps found)
• 2-aminoethylphosphonate degradation II (1/2 steps found)
• 2-aminoethylphosphonate biosynthesis (1/3 steps found)

KEGG Metabolic Maps

• Aminophosphonate metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.6.1.37

Protein Sequence (362 amino acids)

>ABI39_RS15035 2-aminoethylphosphonate--pyruvate transaminase (Phocaeicola dorei CL03T12C01)
MRPYLLLTPGPLTTSESVKTAMMTDWCTWDEDYNVHIVEEIRKGLVQLATRKTDDYTSIL
MQGSGTYCVEATLGSVITPKHKLLILSNGAYGDRMGNIAEYHGMNYDMLAFDETEQVSVE
YVDDYLAHNAEITHVAVVHCETTTGILNPLKEIAHMVKMHGKKLIVDAMSSFGGVPLDVE
ELGIDFMISSANKCIQGVPGFGFIIARKSELQYCKGVSKSLSLDIYDQWDAMEKGHGKWR
FTSPTHVVRAFKQAMDELAAEGGVEARHARYCRNHDVLVEGMRSLGFKTLLKDEVQSPII
TSFLYPDKEFDFKEFYHQLKEKGFVIYPGKISQADTFRIGNIGDVFPEDFSRLIEAIKTV
AK