Protein Info for ABI39_RS12390 in Phocaeicola dorei CL03T12C01

Annotation: heavy metal translocating P-type ATPase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 569 transmembrane" amino acids 15 to 42 (28 residues), see Phobius details amino acids 182 to 203 (22 residues), see Phobius details amino acids 216 to 240 (25 residues), see Phobius details amino acids 521 to 540 (20 residues), see Phobius details amino acids 546 to 565 (20 residues), see Phobius details TIGR01525: heavy metal translocating P-type ATPase" amino acids 14 to 566 (553 residues), 535.5 bits, see alignment E=2.8e-164 TIGR01494: HAD ATPase, P-type, family IC" amino acids 36 to 544 (509 residues), 223 bits, see alignment E=8.2e-70 PF00122: E1-E2_ATPase" amino acids 64 to 249 (186 residues), 139.4 bits, see alignment E=9.6e-45 PF00702: Hydrolase" amino acids 265 to 475 (211 residues), 101 bits, see alignment E=1.1e-32

Best Hits

KEGG orthology group: K01534, Cd2+/Zn2+-exporting ATPase [EC: 3.6.3.3 3.6.3.5] (inferred from 99% identity to bvu:BVU_2484)

Predicted SEED Role

"Lead, cadmium, zinc and mercury transporting ATPase (EC 3.6.3.3) (EC 3.6.3.5); Copper-translocating P-type ATPase (EC 3.6.3.4)" (EC 3.6.3.3, EC 3.6.3.4, EC 3.6.3.5)

Isozymes

Compare fitness of predicted isozymes for: 3.6.3.3, 3.6.3.4, 3.6.3.5

Use Curated BLAST to search for 3.6.3.3 or 3.6.3.4 or 3.6.3.5

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (569 amino acids)

>ABI39_RS12390 heavy metal translocating P-type ATPase (Phocaeicola dorei CL03T12C01)
MKKIKLESVFNEFTLMGIAVSGAFYLGEYWEGIAVILFYLIGEWFQHKAVHKARSNIKAL
LDVRPETATVVYNNTYKITAPEKVQPGETIEVKVGEKVPLDGFLLEDSASFNTAALTGES
VPRTLYKQEEVLAGMIASDKVVRIKVNKPYDQSTLARILTLVQDAAERKAPAELFIRRFA
RIYTPIVTGLAILVVILPYLYSLIKPEFIFVFDDWFYRALVFLVISCPCALVVSIPLGYF
GGIGAASHKGILFKGGNYLDAITQINTVVFDKTGTLTQGVFSVQAISAAEGVSQKELLQL
IASIESFSNHPIAKAIVKYAEEQSISLNSSLRITEFAGYGIKAVTNGKEVYVGNTRLLSK
YGISFPYEISNMTETIVLCAMENKYLGYLSLADTPKPDAVQAIRELKDLNINNIQILSGD
KQTIVSNLAEKIGVTHAFGDLLPEGKVAHLEQLKANFENRVAFVGDGINDTPVLALSDVG
IAMGGLGCDAAIETADVVIQTDQPSKVAEAIKIGKQTHRIVWQNISMAFGVKLLVLLLGA
GGMATMWEAIFADVGVALLAIFNAMRIQK