Protein Info for ABI39_RS08170 in Phocaeicola dorei CL03T12C01

Annotation: RIP metalloprotease RseP

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 447 transmembrane" amino acids 6 to 29 (24 residues), see Phobius details amino acids 106 to 131 (26 residues), see Phobius details amino acids 379 to 406 (28 residues), see Phobius details amino acids 418 to 439 (22 residues), see Phobius details TIGR00054: RIP metalloprotease RseP" amino acids 8 to 446 (439 residues), 206.2 bits, see alignment E=4e-65 PF02163: Peptidase_M50" amino acids 11 to 433 (423 residues), 176.5 bits, see alignment E=8e-56 PF00595: PDZ" amino acids 223 to 257 (35 residues), 26.9 bits, see alignment 8e-10

Best Hits

KEGG orthology group: K11749, regulator of sigma E protease [EC: 3.4.24.-] (inferred from 97% identity to bvu:BVU_1652)

Predicted SEED Role

"Membrane-associated zinc metalloprotease" in subsystem Sex pheromones in Enterococcus faecalis and other Firmicutes

Isozymes

Compare fitness of predicted isozymes for: 3.4.24.-

Use Curated BLAST to search for 3.4.24.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (447 amino acids)

>ABI39_RS08170 RIP metalloprotease RseP (Phocaeicola dorei CL03T12C01)
METFLIRALQLIMSLSLLVIIHEGGHFLFSRLFKVRVEKFYIFFDPWFSLFKFKPKNSDT
EYGIGWVPLGGYVKISGMIDESMDTEQMKQPAKPWEFRSKPAWQRLLIMVGGVLMNFLLA
IFIYSMILFHWGDSFVSLQDMTHGMKFNERAREIGFRDGDILLRADEKPLERFGMDMLRD
IAEARTVTVSRDGKETEVYMPEISLLDIAKDDPMFVTALVPNVVDSVIPGGGLDKAGIQK
GDSLIAVNGEMLNSWNALVEKLDNMQADAETTGDKGVAMQMVYSRGGLRDTVTVHTDSLF
RVGATFLSLADYKETTREYGFFESFPAGVQLGVNTLKGYVNDMKYVFTKEGAKSVGGFGT
IGSIFPKVWDWHRFWEMTAFLSIILAFMNILPIPALDGGHVLFLLYEIIARRKPSDKFME
YAQMVGMFLLFALLIWANFNDIMRFLF