Protein Info for ABI39_RS04205 in Phocaeicola dorei CL03T12C01

Annotation: nucleoside kinase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00485: PRK
  • amino acids 297 to 492 (196 residues), 63.9 bits, E=9.4e-22

Best Hits

KEGG orthology group: K00876, uridine kinase [EC: 2.7.1.48] (inferred from 98% identity to bvu:BVU_1422)

Predicted SEED Role

"Uridine kinase (EC 2.7.1.48)" (EC 2.7.1.48)

MetaCyc Pathways

• superpathway of pyrimidine ribonucleosides salvage (9/10 steps found)
• pyrimidine ribonucleosides salvage I (3/3 steps found)
• nucleoside and nucleotide degradation (archaea) (4/10 steps found)

KEGG Metabolic Maps

• Drug metabolism - other enzymes
• Pyrimidine metabolism

Isozymes

Compare fitness of predicted isozymes for: 2.7.1.48

Use Curated BLAST to search for 2.7.1.48

Protein Sequence (557 amino acids)

>ABI39_RS04205 nucleoside kinase (Phocaeicola dorei CL03T12C01)
MTIMLQICCKNNNISKNFPIGSSLLDIYNGFNLDIPYGPVSAKVNNKVEGLNYRAYNNKD
VEFLNMLNPSGMRTYVRSLCFILCKAVEDLYPDGKIMLEHPVSKGYYCDLQIGHETGLDD
VSRIKQRMKEIVEANIPFHRFECHTTKVVELFCRKGMMDKVKLLETSGELYSYYYTLENT
IDYYYGSLLPSTGYIRKFDIVKYYDGLLLRVPNRQNPEVLEEVVKQEKMLEVFKEHRRWN
QILGVGTVGDFNVACNEGYATDLINVSEALQEKKISNIADGIYHRGKNGQRVKLVLISGP
SSSGKTTFSKRLSIQLMANGLKPYPISLDNYFVDREKTPKDEKGDYDYESLYALDLEFFN
KQLQDLLHGKEVELPRFNFTTGRREFKGDKLKIDDNMILILEGIHALNPELTPHIPTENK
YKIYVSALTTILLDNHNYIPTTDNRLLRRIIRDHKYRGYSAEETIRRWPSVRAGEEKWIF
PYQENADAMFNSALLFELAIMKDYAIPILRNVPNNKPEYSEAYRLRKFLEYFASVQDKEL
PPTSLLREFLGGSSFRY