Protein Info for A4249_RS16995 in Brevundimonas sp. GW460-12-10-14-LB2

Annotation: phosphoglycerate dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 630 PF00702: Hydrolase" amino acids 6 to 180 (175 residues), 53.2 bits, see alignment E=1e-17 TIGR01488: HAD phosphoserine phosphatase-like hydrolase, family IB" amino acids 7 to 180 (174 residues), 65.5 bits, see alignment E=3.1e-22 PF12710: HAD" amino acids 8 to 179 (172 residues), 56.9 bits, see alignment E=7.7e-19 PF00389: 2-Hacid_dh" amino acids 236 to 547 (312 residues), 117.1 bits, see alignment E=9.6e-38 PF02826: 2-Hacid_dh_C" amino acids 338 to 515 (178 residues), 161.8 bits, see alignment E=2.2e-51

Best Hits

KEGG orthology group: K00058, D-3-phosphoglycerate dehydrogenase [EC: 1.1.1.95] (inferred from 80% identity to bsb:Bresu_1707)

Predicted SEED Role

"D-3-phosphoglycerate dehydrogenase (EC 1.1.1.95)" in subsystem Glycine and Serine Utilization or Pyridoxin (Vitamin B6) Biosynthesis or Serine Biosynthesis (EC 1.1.1.95)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 1.1.1.95

Use Curated BLAST to search for 1.1.1.95

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A161I6N1 at UniProt or InterPro

Protein Sequence (630 amino acids)

>A4249_RS16995 phosphoglycerate dehydrogenase (Brevundimonas sp. GW460-12-10-14-LB2)
MSARPTLIFDFDSTLVDFETLEGLADIALAEAPGAVETRTQIAALTDQAMAGEIEFGEAL
RRRLALLPLTRAHVAALAQSASDHLTASVRRNLNFFQQNKGKVVILSGGFREVIAPVAEE
LGVSADRVLCNDLIYDADDRVVGVDDANPLSHANGKPTAIHGLNLSGRVVMVGDGWNDAE
VKIAGAADAFYAFTEVVRRPPVVQVADAEAASLDEVLHAEGLVGRWSFPRSRMKMLLLEN
IHPAAVERLEEAGYSVETQKGALDEDDLIAAIKGVHVLGIRSKTTVSRRVLEQADRLMAV
AAFCIGTNQIDLDAASDHGVAVFNAPYSNTRSVVELAIGLMIVLMRDVADKSAAMHVGKW
NKSATGSKELRGKTLGIVGYGAIGSQLSVLAENLGMRVLFYDLSERLALGNARRMRSLDA
LLAESDVVTLHVDGRKENANIFGAAQFGRMKEGALFLNLARGHVVDVGALSQAIGSGRVA
GAAVDVFPEEPRTNADPFESPLQGLPNMILTPHIGGSTEEAQEAIAEFAAERLLGYLNRG
DTTFSVNLPNVQLSEVSGAHRILHIHRNQPGVLAELNRALASAGLNILGQHLKTDERTGY
VITDVDRDYDPEALRELKTVPGTLKFRTLQ