Protein Info for A4249_RS15945 in Brevundimonas sp. GW460-12-10-14-LB2

Annotation: ATP-dependent zinc metalloprotease FtsH

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 651 signal peptide" amino acids 1 to 25 (25 residues), see Phobius details transmembrane" amino acids 108 to 129 (22 residues), see Phobius details PF06480: FtsH_ext" amino acids 11 to 103 (93 residues), 45.3 bits, see alignment E=2.2e-15 TIGR01241: ATP-dependent metallopeptidase HflB" amino acids 109 to 602 (494 residues), 783.2 bits, see alignment E=5.2e-240 PF07728: AAA_5" amino acids 198 to 318 (121 residues), 24 bits, see alignment E=8.4e-09 PF00004: AAA" amino acids 198 to 329 (132 residues), 163.3 bits, see alignment E=9.8e-52 PF17862: AAA_lid_3" amino acids 352 to 396 (45 residues), 57.4 bits, see alignment 2e-19 PF01434: Peptidase_M41" amino acids 411 to 601 (191 residues), 239.7 bits, see alignment E=5.9e-75

Best Hits

Swiss-Prot: 77% identical to FTSH_CAUVN: ATP-dependent zinc metalloprotease FtsH (ftsH) from Caulobacter vibrioides (strain NA1000 / CB15N)

KEGG orthology group: K03798, cell division protease FtsH [EC: 3.4.24.-] (inferred from 86% identity to bsb:Bresu_0868)

MetaCyc: 63% identical to ATP-dependent zinc metalloprotease FtsH (Escherichia coli K-12 substr. MG1655)
3.4.24.-

Predicted SEED Role

"Cell division protein FtsH (EC 3.4.24.-)" in subsystem Bacterial Cell Division (EC 3.4.24.-)

Isozymes

Compare fitness of predicted isozymes for: 3.4.24.-

Use Curated BLAST to search for 3.4.24.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A161I7C0 at UniProt or InterPro

Protein Sequence (651 amino acids)

>A4249_RS15945 ATP-dependent zinc metalloprotease FtsH (Brevundimonas sp. GW460-12-10-14-LB2)
MNLRNLAITGVIILALLAGYAALSQGGAMNGVTGQPAGKPEAISYSQLVQRVNAGEVKQV
TIRLDKVNGELKNGERFTSTTVYPNEQLVAQMLAANVEIDAKSGGQSIWMSLLLGILPIA
LLIGVWIFFMRQMQGGAKGAMGFGKSKAKLLTEHKGRKTFDDVAGVDEAKDELQEVVDFL
KDPGKFQRLGGKIPKGALLVGPPGTGKTLLARAVAGEAGVPFFSISGSDFVEMFVGVGAS
RVRDMFEQAKKNAPCIIFIDEIDAVGRHRGAGLGGGNDEREQTLNQLLVEMDGFEASENI
ILIAATNRPDVLDPALLRPGRFDRQVVVPNPDVSGRERILRVHMKDVPLAADVNVKTIAR
GTPGFSGADLANLVNEAALTAARKDRRMVTHRDFEDAKDKVLMGSERRSMAMNEEEKRLT
AYHEAGHAIVAMNVKMADPVHKATIVPRGRALGMVMQLPEGDRYSMKYQQMIDRIAIMAG
GRVAEELIFGPENITSGASSDIEQATKLARAMVTRWGFSDKLGTVAYGENQEEVFLGHSV
ARSQNISEETARTIDEEVRRLVTSGWDEARTILTTKAEDHEKLSQALLEYETLSGEEIKD
LLEKGVAPNRDENNFPNAGPSVSVPVTPVSDGTDIEVPVAAPAATSVPTVH