Protein Info for A4249_RS15860 in Brevundimonas sp. GW460-12-10-14-LB2

Annotation: Holliday junction branch migration protein RuvA

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 205 PF01330: RuvA_N" amino acids 1 to 63 (63 residues), 57.9 bits, see alignment E=1.3e-19 PF14520: HHH_5" amino acids 73 to 130 (58 residues), 42.1 bits, see alignment E=1.5e-14 PF07499: RuvA_C" amino acids 158 to 203 (46 residues), 37.1 bits, see alignment 5.3e-13

Best Hits

Swiss-Prot: 69% identical to RUVA_CAUVN: Holliday junction ATP-dependent DNA helicase RuvA (ruvA) from Caulobacter vibrioides (strain NA1000 / CB15N)

KEGG orthology group: K03550, holliday junction DNA helicase RuvA (inferred from 88% identity to bsb:Bresu_3185)

Predicted SEED Role

"Holliday junction DNA helicase RuvA" in subsystem DNA-replication or RuvABC plus a hypothetical

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A160I293 at UniProt or InterPro

Protein Sequence (205 amino acids)

>A4249_RS15860 Holliday junction branch migration protein RuvA (Brevundimonas sp. GW460-12-10-14-LB2)
MIGRLRGVLAEVGEAECLIDCAGVGYVVSCGARTLGRLPAPGDEATVHVHSQWSEDAGPR
LYGFLTRDERRAFTTLLAIQGVGPKAALAVLDVLPPGELASAVAREDKAAVARANGVGPK
LALRIVTELKGKPLGDVSFAPVAPGMHIEIAPPVPSITGEAVSALLGLGVAEVNARRAVD
QALIRLGEEAELSAVIRAALQELGR