Protein Info for A4249_RS15810 in Brevundimonas sp. GW460-12-10-14-LB2

Annotation: retropepsin-like aspartic protease

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 302 signal peptide" amino acids 1 to 30 (30 residues), see Phobius details PF13650: Asp_protease_2" amino acids 64 to 149 (86 residues), 30.8 bits, see alignment E=3.8e-11 amino acids 198 to 276 (79 residues), 25.8 bits, see alignment E=1.4e-09

Best Hits

KEGG orthology group: None (inferred from 82% identity to aex:Astex_2421)

Predicted SEED Role

No annotation

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A160I0K5 at UniProt or InterPro

Protein Sequence (302 amino acids)

>A4249_RS15810 retropepsin-like aspartic protease (Brevundimonas sp. GW460-12-10-14-LB2)
MIRSLFKRAMAASCLAGVSLSAGLAAAQAEPVSQATPQSTAPAPAAAVARIPLYVSDGRA
LLMMRINGGHPAPVVFDTGTNGNLIYKSYADDIGMPNVGPSQSRDGSTGLMVPGYTTSLK
GVTLGGYAITEGPATVFEFRDEDEVGIFGPNSFPGKLVEMNLAKGELRIMAPDAPQRPEG
PGHAYSDDERLPVVALDLPGASVEATLDTGNDSAFLLPLSLVSQIKLKGEPRKIGIATSA
AGTQPVYEAQADGPVKVGGVEVDSPKLRFIEGGTPNVGLPMMRKFRFVFDPTNERTWVLA
GD