Protein Info for A4249_RS15630 in Brevundimonas sp. GW460-12-10-14-LB2

Annotation: sensor histidine kinase KdpD

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 867 transmembrane" amino acids 368 to 387 (20 residues), see Phobius details amino acids 399 to 426 (28 residues), see Phobius details amino acids 446 to 466 (21 residues), see Phobius details PF02702: KdpD" amino acids 1 to 200 (200 residues), 286.8 bits, see alignment E=1.8e-89 PF13493: DUF4118" amino acids 372 to 476 (105 residues), 82 bits, see alignment E=5.2e-27 PF00512: HisKA" amino acids 633 to 699 (67 residues), 50.9 bits, see alignment 2.6e-17 PF02518: HATPase_c" amino acids 744 to 858 (115 residues), 79.4 bits, see alignment E=5.8e-26

Best Hits

KEGG orthology group: K07646, two-component system, OmpR family, sensor histidine kinase KdpD [EC: 2.7.13.3] (inferred from 77% identity to bsb:Bresu_3237)

Predicted SEED Role

"Osmosensitive K+ channel histidine kinase KdpD (EC 2.7.3.-)" in subsystem Potassium homeostasis (EC 2.7.3.-)

Isozymes

Compare fitness of predicted isozymes for: 2.7.13.3, 2.7.3.-

Use Curated BLAST to search for 2.7.13.3 or 2.7.3.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A161IJ95 at UniProt or InterPro

Protein Sequence (867 amino acids)

>A4249_RS15630 sensor histidine kinase KdpD (Brevundimonas sp. GW460-12-10-14-LB2)
MSPGVGKTYEMLRAARRRKAEGLDVVVGVVETHGRKETMSLLRGLDVMPRAPIEHRDRAL
MEFDLDGALARRPELLLVDEYAHSNAPGSRHPKRWQDVEELRDAGIDVWTTLNIQHLESL
SDVILRITGVRQREAVPDSALTGADDIEVIDITPEDLRARLAEGKVYVPETARVASENFF
KIENLTALRELALRRAAQTVDDQLLTHLRERGVSGPWAANERILVLVGGDAMTASLVRTG
RRMSDMMMDAPWSVAHVERPSGSRADARSAGRLSEAFKLAEQLGGRPVTISGDDVVRAVL
DHAHRNNVTQIVIGKTRGGRFAEWTGRALATELLRKAQGVAVHVVTEGDLVAPEPAAKSG
VRAALDWRGYPAGAGFVLAATGAALLLDTRFERVDLGVIYLAAVVAAGVLNGLRPALAAA
TLAFLTYNFLFLQPRYSFLIGSPTDFLTLLLFWGVALGTGALAGRVREQARAAQRRAAAV
SALLAASQTLSAGQDRATTARSLAEQASAAAGAGAVVLLPDGEDIVLTAASPDGVTLTPD
AMAAARWAWTHGEVTGHGTGTLPQTHWRFQPLQGVRGRAGVAGVDASAVAAGSDEERLAM
ALLDQGAVALERADLAGQALETETLRRADRFRAALMNSVSHDLRTPLSTVLGSATTLIDY
GATLKPEVRDDLLLSIREEAERLSRYVGDLLDMTRLEGGGLNVRTDWTDVRDILNTAADR
VSRRLGRRKVTRDFPAQLSMVEADPGLLEQAVVNILENAIAYSPDGTTIELAAYEDRGAV
VISIEDEGRGIPTAELERVFDKFRRMEESTDRAKGAGLGLAIAKGFVEAMRGRIAAASPI
QDDADGKRGTRILISLPKSIATHPDLL