Protein Info for A4249_RS15565 in Brevundimonas sp. GW460-12-10-14-LB2

Annotation: chemotaxis protein CheA

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 749 PF01627: Hpt" amino acids 9 to 96 (88 residues), 56.2 bits, see alignment E=6.9e-19 PF02895: H-kinase_dim" amino acids 353 to 414 (62 residues), 56.7 bits, see alignment 5.4e-19 PF02518: HATPase_c" amino acids 460 to 599 (140 residues), 72.6 bits, see alignment E=7.1e-24 PF01584: CheW" amino acids 605 to 735 (131 residues), 78.2 bits, see alignment E=9.8e-26

Best Hits

KEGG orthology group: K03407, two-component system, chemotaxis family, sensor kinase CheA [EC: 2.7.13.3] (inferred from 58% identity to pzu:PHZ_c3379)

Predicted SEED Role

"Signal transduction histidine kinase CheA (EC 2.7.3.-)" in subsystem Bacterial Chemotaxis or Flagellar motility or Two-component regulatory systems in Campylobacter (EC 2.7.3.-)

Isozymes

Compare fitness of predicted isozymes for: 2.7.13.3, 2.7.3.-

Use Curated BLAST to search for 2.7.13.3 or 2.7.3.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A160I270 at UniProt or InterPro

Protein Sequence (749 amino acids)

>A4249_RS15565 chemotaxis protein CheA (Brevundimonas sp. GW460-12-10-14-LB2)
MDAFEAIKATFFQECDELLADLEAKLMLLEQGQTDLETINAVFRAVHSVKGGAGAFGLEA
LVRFAHVFETLMDELRAGRKPCDAITIKTLLRASDVLADHIQAAQGLIPPVDEARSAALV
AEMQVLTHGGEAPVEVEEDEDDFGFTPMAFDMALDEPAPLPIADLGADAPSVGWRIVFKP
MGRMYVNANETSLLLRELGRLGPVTVVVDDSETPTLDALSIEDGCLTWTVDLAAAVDEAA
VREVFDFVESDCDLTITPLGAGGATDIVAFDDEPAAVLPASDDLDIAALLAKAAGAAAEP
AAEVVPFAPLELEPAPAPIAAAPAVEPAAAPVAAPVAATPAPASAPVAPAPVTIRVDLDR
VDRLINVVGELVIQQAMLSQRVLESGLARSSGIALGLEDLELLTREIQDSVMAIRAQPVK
SVFQRMPRLVREVADMVSKQVRLVTAGEDTEVDKTVVERLAEPITHMLRNAIDHGLETPE
ERVAAGKPAEGAVRLAALHRSGRIVIEISDDGRGINRERVKKIAVDKGLIAADAPLTDEQ
IDNLIFAPGFSTAAVVSDISGRGVGMDVVKRSIQALGGRISISSVPGKGSTFTLSLPLTL
AVLDGMVVAAAEQTLIAPLPAIVESLTPQAIDLHFVGGVDPVIRFRDRFLPLIDVALIMG
FREQPMNPTEGVAVVVETEGGQQAALLFDAIQGQRQVVIKSLETNYQQVEGVAAATILGD
GRVALILDVDVLVTDMRRKSVRPDFKLAS