Protein Info for A4249_RS15295 in Brevundimonas sp. GW460-12-10-14-LB2

Annotation: mechanosensitive ion channel

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 349 transmembrane" amino acids 25 to 48 (24 residues), see Phobius details amino acids 68 to 90 (23 residues), see Phobius details amino acids 97 to 119 (23 residues), see Phobius details PF21088: MS_channel_1st" amino acids 75 to 112 (38 residues), 26.1 bits, see alignment 1.1e-09 PF00924: MS_channel_2nd" amino acids 114 to 181 (68 residues), 67.9 bits, see alignment E=1e-22 PF21082: MS_channel_3rd" amino acids 191 to 276 (86 residues), 28.3 bits, see alignment E=2.9e-10

Best Hits

KEGG orthology group: None (inferred from 72% identity to bsb:Bresu_0725)

Predicted SEED Role

No annotation

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A160I208 at UniProt or InterPro

Protein Sequence (349 amino acids)

>A4249_RS15295 mechanosensitive ion channel (Brevundimonas sp. GW460-12-10-14-LB2)
MTNPIQKLDLDTIEQSQIARIAGINLTLGGLVSAGVILLIAFAAHWLVTRSLRRVRERSD
RSRQAIYLLERLAGYGIIAVGVMSALSAAGLNLSSLTVFAGALGIGVGLGLQGVVKEFVS
GLFLIFDRMVSVGDYIEIEDIGIRGAIMEIGPRATRVRTNDNVNVLVPNSRFIEQPVTNW
TMKGDTRRIHVPFTVAYGSDRGQVRDAVLAAARASPFTLPETEARKSQVWLVAFGDRGLS
FELVVWPTRDAVKRPAAMHAAYTWLIADALDAAGVEVPVPQTDLRLRTAFGLDGEEALKR
LGYGVGSPPRPTGPQSPARTANDAADDVMANDEAEMPEPLAPPRARQTD