Protein Info for A4249_RS15105 in Brevundimonas sp. GW460-12-10-14-LB2
Annotation: malonic semialdehyde reductase
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 64% identical to Y018_CAUSK: Putative NADH dehydrogenase/NAD(P)H nitroreductase Caul_0018 (Caul_0018) from Caulobacter sp. (strain K31)
KEGG orthology group: K09019, putative NADH dehydrogenase/NAD(P)H nitroreductase RutE [EC: 1.-.-.-] (inferred from 66% identity to cse:Cseg_0013)MetaCyc: 52% identical to putative malonic semialdehyde reductase (Escherichia coli K-12 substr. MG1655)
RXN-8974 [EC: 1.1.1.298]
Predicted SEED Role
"Oxygen-insensitive NADPH nitroreductase (EC 1.-.-.-)" (EC 1.-.-.-)
MetaCyc Pathways
- β-alanine degradation III (1/2 steps found)
- uracil degradation III (3/5 steps found)
- 3-hydroxypropanoate cycle (8/13 steps found)
- 3-hydroxypropanoate/4-hydroxybutanate cycle (11/18 steps found)
- glyoxylate assimilation (5/13 steps found)
- superpathway of the 3-hydroxypropanoate cycle (8/18 steps found)
KEGG Metabolic Maps
- Alkaloid biosynthesis I
- Carotenoid biosynthesis - General
- Insect hormone biosynthesis
- Nucleotide sugars metabolism
- Porphyrin and chlorophyll metabolism
- Puromycin biosynthesis
- Trinitrotoluene degradation
- alpha-Linolenic acid metabolism
Isozymes
Compare fitness of predicted isozymes for: 1.-.-.-
Use Curated BLAST to search for 1.-.-.- or 1.1.1.298
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See A0A160I216 at UniProt or InterPro
Protein Sequence (204 amino acids)
>A4249_RS15105 malonic semialdehyde reductase (Brevundimonas sp. GW460-12-10-14-LB2) MAYDATHQRDVPLSDAALSQLFTEARTRNGWTDRPVAPELLRKLYDLTKFGPTAVNGSPA RFVFITSPEAKARLIPLMSEGNRDKTQQAPVTVIVGQDMDFHDHLDALFPHAPGAKAWFA DEAGRRETAFRNASLQGGYLTIAARALGLDVGPMSGFDAAGVKAEFFPDSHVEPNYILNL GYGSDENLFPRSPRLSFDEAAQIL