Protein Info for A4249_RS15075 in Brevundimonas sp. GW460-12-10-14-LB2

Annotation: ActR/PrrA/RegA family redox response regulator transcription factor

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 184 PF00072: Response_reg" amino acids 17 to 125 (109 residues), 88 bits, see alignment E=5e-29 PF02954: HTH_8" amino acids 147 to 176 (30 residues), 28.6 bits, see alignment 9.7e-11

Best Hits

Swiss-Prot: 72% identical to REGA_RHOCA: Photosynthetic apparatus regulatory protein RegA (regA) from Rhodobacter capsulatus

KEGG orthology group: K15012, two-component system, response regulator RegA (inferred from 86% identity to bsb:Bresu_0526)

Predicted SEED Role

"Dna binding response regulator PrrA (RegA)"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A160I098 at UniProt or InterPro

Protein Sequence (184 amino acids)

>A4249_RS15075 ActR/PrrA/RegA family redox response regulator transcription factor (Brevundimonas sp. GW460-12-10-14-LB2)
MSELEARIAALPDKSLLLLDDDQALRTRMGRALEARGFQVTTAESVAEAMQLLRDKAPAF
AVLDMRLEDGNGLKIVEAVREKREDARIVMVTGYGAIATAVAAVKAGAVDYLSKPADADD
VVKALLATGDSPEPPENPMSADRVRWEHIQRVYELCDHNVSETARRLGMHRRTLQRILAK
RAPR