Protein Info for A4249_RS14635 in Brevundimonas sp. GW460-12-10-14-LB2

Annotation: hemolysin III family protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 237 transmembrane" amino acids 34 to 61 (28 residues), see Phobius details amino acids 65 to 87 (23 residues), see Phobius details amino acids 99 to 116 (18 residues), see Phobius details amino acids 123 to 146 (24 residues), see Phobius details amino acids 153 to 173 (21 residues), see Phobius details amino acids 179 to 199 (21 residues), see Phobius details amino acids 210 to 234 (25 residues), see Phobius details PF03006: HlyIII" amino acids 33 to 222 (190 residues), 81.8 bits, see alignment E=3.1e-27

Best Hits

KEGG orthology group: K11068, hemolysin III (inferred from 76% identity to bsb:Bresu_3228)

Predicted SEED Role

"COG1272: Predicted membrane protein hemolysin III homolog"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A168NRW7 at UniProt or InterPro

Protein Sequence (237 amino acids)

>A4249_RS14635 hemolysin III family protein (Brevundimonas sp. GW460-12-10-14-LB2)
MLRTLKRLVTHVCTPDELDMIEHYPTRAEKLADLWVHVVGLMLAAVGGIILAGLAGVYAG
IGGVMATAIYALCLVGMLTASTIYNWTNPCAARPVLRRLDEAAIFLMIAGSYTPFTTQRF
EGLWAIGFTTLIWTLAFLGAGVKLFAPRISDKFWSGVYVVFGWLAVAALKPMVETVHPIA
LALLVIGGLIYTAGVFVFISPRVKFRRAIWHGFVVTGATVHWTAVLVGVVLAPAMSH