Protein Info for A4249_RS14525 in Brevundimonas sp. GW460-12-10-14-LB2

Annotation: thioredoxin family protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 724 signal peptide" amino acids 1 to 23 (23 residues), see Phobius details transmembrane" amino acids 317 to 343 (27 residues), see Phobius details amino acids 364 to 385 (22 residues), see Phobius details amino acids 402 to 424 (23 residues), see Phobius details amino acids 444 to 469 (26 residues), see Phobius details amino acids 473 to 497 (25 residues), see Phobius details amino acids 516 to 535 (20 residues), see Phobius details amino acids 543 to 563 (21 residues), see Phobius details amino acids 575 to 598 (24 residues), see Phobius details PF11412: DsbD_N" amino acids 49 to 163 (115 residues), 60.4 bits, see alignment E=2.7e-20 PF02683: DsbD" amino acids 325 to 503 (179 residues), 30.4 bits, see alignment E=5.2e-11 PF13899: Thioredoxin_7" amino acids 615 to 701 (87 residues), 69.6 bits, see alignment E=3.1e-23

Best Hits

Predicted SEED Role

"Cytochrome c-type biogenesis protein DsbD, protein-disulfide reductase (EC 1.8.1.8)" in subsystem Biogenesis of c-type cytochromes or Periplasmic disulfide interchange (EC 1.8.1.8)

Isozymes

Compare fitness of predicted isozymes for: 1.8.1.8

Use Curated BLAST to search for 1.8.1.8

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A160I2C6 at UniProt or InterPro

Protein Sequence (724 amino acids)

>A4249_RS14525 thioredoxin family protein (Brevundimonas sp. GW460-12-10-14-LB2)
MRLFALLLGLLFSLTGVSATVAQPVQSQPTGVVAFGPQRTERIEAELVPMSQWVAPGSTT
VVAVRQKIAPDWHTYWRNPGDSGGATSLIWTLPAGVTADPILWPLPSRQRLMSLMNYGYS
GAVLLPVPIHVPPTARPGEVLTLTTDVLFLVCSDQMCVPEPMTLSLALPVREGAAPLAKP
WGEEIERLVETAPRPAGIEARVTRQGGQLILTATGGPLSGDQAGADISQVYFYPFDGGRI
DHAAAQSGQRGPNGLTLTLTAGKDAAQTALTGVLATDKGAWEITAEPGAPLAGAQGGAAL
KPLDDATKTLAKTGALVFLQALGLALLGGLVLNLMPCVFPVLAMKAASLSAAAHDPARAR
RDGLAFTAGVLVSFLVLAGVLLALRAAGQAIGWGFQLQSPGVVAALALVMLLVGLNLSGV
FHVGAGLQNAGSGPLSRLPGSAGAFFTGVLAVVVAAPCTAPFMAVALGAALVLAWPMALA
VFLMLGLGLALPYLAITLSPGLLSRLPRPGVWMERLKGLLAFPMYGAALWLLWVFTRQGG
VDALGLLLTAALLLALAAWLTGLAQAARQGDERPILTTICAIVVGVLALGLAGVAAGAAR
DADAAPQGDSGPLAAQPWSTAAVKAATASGRPVLVNLTADWCVTCKINERAALSSPRVAE
AMRKANAAYLVGDWTRRDDAITRELQAHGRSGVPLYLLYRPGRAEPEILPQLLTEGVVVD
ALKD