Protein Info for A4249_RS14450 in Brevundimonas sp. GW460-12-10-14-LB2

Annotation: peptide chain release factor 1

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 355 TIGR00019: peptide chain release factor 1" amino acids 7 to 351 (345 residues), 486.3 bits, see alignment E=2.6e-150 PF03462: PCRF" amino acids 13 to 199 (187 residues), 224.9 bits, see alignment E=8.5e-71 PF00472: RF-1" amino acids 207 to 315 (109 residues), 134 bits, see alignment E=2.4e-43

Best Hits

Swiss-Prot: 76% identical to RF1_CAUVC: Peptide chain release factor 1 (prfA) from Caulobacter vibrioides (strain ATCC 19089 / CB15)

KEGG orthology group: K02835, peptide chain release factor 1 (inferred from 86% identity to bsb:Bresu_0318)

Predicted SEED Role

"Peptide chain release factor 1" in subsystem LMPTP YwlE cluster

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A160I008 at UniProt or InterPro

Protein Sequence (355 amino acids)

>A4249_RS14450 peptide chain release factor 1 (Brevundimonas sp. GW460-12-10-14-LB2)
MRLPQARLDQVLDRFHEVEARMGSATDGAEIVRLSKEHAELKPVVDAVQGLARARAEMAD
LEAMTADPEMAAMAEEELRALTDRLPELEREVALLLAPRDADENASAVLEVRAGTGGDEA
ALFAGDLFRMYSRYASTRGWRIELDSATEGDAGGYKEIIATVTGEGVFGRLKFESGVHRV
QRVPTTESQGRIHTSAATVAVLPEVEDVEIEIHDKDIRIDTFRASGSGGQHVNTTDSAVR
ITHLPTGIMVTSSEKSQHVNRDKAMKNLRVRLYDMQRQAKDLARSDSRKSQVGSGDRSER
IRTYNYPQGRVSDHRINLTLHSLPQIMEGDIDPLLNALIAEDQAARLADLEAEFG